AF4/FMR2 family member 1 (AFF1), known as a central scaffolding protein of super elongation complex (SEC), regulates gene transcription. We previously reported that AFF1 inhibited osteogenic differentiation of human mesenchymal stromal/stem cells (hMSCs). However, its role in adipogenic differentiation has not been elucidated.

中文翻译：

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AFF1 通过靶向 TGM2 转录抑制脂肪分化

AF4/FMR2 家族成员 1 (AFF1)，被称为超延伸复合物 (SEC) 的中心支架蛋白，调节基因转录。我们之前报道过 AFF1 抑制人间充质基质/干细胞 (hMSCs) 的成骨分化。然而，其在成脂分化中的作用尚未阐明。