lncRNA Oip5‐as1 attenuates myocardial ischaemia/reperfusion injury by sponging miR‐29a to activate the SIRT1/AMPK/PGC1α pathway,Cell Proliferation

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lncRNA Oip5‐as1 attenuates myocardial ischaemia/reperfusion injury by sponging miR‐29a to activate the SIRT1/AMPK/PGC1α pathway
Cell Proliferation ( IF 5.9 ) Pub Date : 2020-05-28 , DOI: 10.1111/cpr.12818
Xiaowei Niu _{1,

2,

3,

4} , Shuangshuang Pu ₅ , Chun Ling ₆ , Jizhe Xu _{1,

2,

3,

4} , Jing Wang ₇ , Shaobo Sun ₈ , Yali Yao _{1,

2,

3,

4} , Zheng Zhang _{1,

2,

3,

4}

Affiliation

Myocardial ischaemia/reperfusion (MI/R) injury is associated with adverse cardiovascular outcomes after acute myocardial infarction. However, the molecular mechanisms underlying MI/R injury are unclear. This study investigated the role of long non‐coding RNA (lncRNA) Oip5‐as1 in regulating mitochondria‐mediated apoptosis during MI/R injury.

中文翻译：

lncRNA Oip5-as1通过海绵miR-29a激活SIRT1/AMPK/PGC1α通路减轻心肌缺血/再灌注损伤

心肌缺血/再灌注 (MI/R) 损伤与急性心肌梗死后的不良心血管结局相关。然而，MI/R 损伤的分子机制尚不清楚。本研究调查了长链非编码 RNA (lncRNA) Oip5-as1 在调节 MI/R 损伤期间线粒体介导的细胞凋亡中的作用。

更新日期：2020-05-28

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