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Novel amidase catalyzed process for the synthesis of vorinostat drug.
Journal of Applied Microbiology ( IF 3.2 ) Pub Date : 2020-06-28 , DOI: 10.1111/jam.14753
R V Singh 1, 2 , H Sharma 1, 2 , A Ganjoo 1 , A Kumar 3 , V Babu 1, 2
Affiliation  

Presently, N‐hydroxy‐N′‐phenyloctanediamide (vorinostat) which is an effective histone deacetylase inhibitor, is being synthesized chemically. Hence, present study aims to develop an eco‐friendly approach for the synthesis of vorinostat from N′‐phenyloctanediamide through biotransformation.

中文翻译:

新型酰胺酶催化的伏立诺他药物合成方法。

目前,化学上正在合成有效的组蛋白脱乙酰基酶抑制剂N-羟基-N'-苯基辛二酰胺(伏立诺他)。因此,本研究旨在开发一种生态友好的方法,通过生物转化从N'-苯基辛二酰胺合成伏立诺他。
更新日期:2020-06-28
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