Glioma is one of the most lethal tumours and common malignant in the central nervous system (CNS), which exhibits diffuse invasion and aggressive growth. Several studies have reported the association of FDPS to tumour development and progression. However, the role of FDPS in progression of glioma and macrophage recruitment is not well‐elucidated. In the current study, a remarkable enhancement in FDPS level was observed in glioma tissues and associated with poor prognosis, contributed to tumour growth. FDPS was correlated with macrophage infiltration in glioma and pharmacological deletion of macrophages largely abrogated the oncogenic functions of FDPS in glioma. Mechanistically, FDPS activated Wnt/β‐catenin signalling pathway and ultimately facilitates macrophage infiltration by inducing CCL20 expression. In conclusion, overexpressed FDPS exhibits an immunomodulatory role in glioma. Therefore, targeting FDPS may be an effective therapeutic strategy for glioma.

中文翻译：

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FDPS通过Wnt /β-catenin信号通路调节CCL20，从而促进神经胶质瘤的生长和巨噬细胞募集。

神经胶质瘤是最致命的肿瘤之一，是中枢神经系统（CNS）常见的恶性肿瘤，表现出弥漫性侵袭和侵袭性生长。几项研究报告了FDPS与肿瘤发展和进展的关系。然而，FDPS在神经胶质瘤和巨噬细胞募集进展中的作用尚不清楚。在当前的研究中，在神经胶质瘤组织中观察到FDPS水平的显着提高，并且与不良的预后相关，这有助于肿瘤的生长。FDPS与胶质瘤中巨噬细胞浸润有关，并且巨噬细胞的药理学缺失大大废除了FDPS在胶质瘤中的致癌作用。从机制上讲，FDPS激活了Wnt /β-catenin信号通路，并最终通过诱导CCL20表达促进了巨噬细胞浸润。结论，过度表达的FDPS在神经胶质瘤中表现出免疫调节作用。因此，靶向FDPS可能是神经胶质瘤的有效治疗策略。