The good biocompatibility and corrosion resistance of the bulk CoCrMo alloy has resulted in it being used in the manufacture of implants and load bearing medical devices. These devices, however, can release wear and corrosion products which differ from the composition of the bulk CoCrMo alloy. The physicochemical characteristics of the particles and the associated in vivo reactivity are dictated by the wear mechanisms and electrochemical conditions at the sites of material loss. Debris released from CoCrMo hip bearings, taper junctions, or cement–stem interfaces can, therefore, have different chemical and morphological characteristics, which provide them with different in vivo toxicities. Here, we propose to assess and compare the characteristics of the particles released in vivo from CoCrMo tapers and cement–stem interfaces which have received less attention compared to debris originating from the hip bearings. The study uses state‐of‐art characterization techniques to provide a detailed understanding of the size, morphology, composition, and chemistry of the particles liberated from the wear and corrosion flakes from revised hip replacements, with an enzymatic treatment. The phase analyses identified Cr₂O₃ nanoparticles released from tapers and cement–stem interfaces, whose composition did not vary with origin or particle morphology. The size distributions showed significantly smaller particles were released from the stems, compared to the particles originating from the corresponding tapers. The investigation demonstrates that the tribocorrosive processes occurring at the taper and stem interfaces both result in Cr₂O₃ nanoparticle formation.

中文翻译：

---

从 CoCrMo 锥体和全髋关节置换的骨水泥 - 干界面在体内释放的纳米粒子的物理化学特性的比较研究。

块状 CoCrMo 合金良好的生物相容性和耐腐蚀性使其被用于制造植入物和承重医疗器械。然而，这些装置会释放出与块状 CoCrMo 合金成分不同的磨损和腐蚀产物。颗粒的物理化学特性和相关的体内反应性由材料损失部位的磨损机制和电化学条件决定。因此，从 CoCrMo 髋关节轴承、锥形接头或骨水泥 - 杆接口释放的碎片可能具有不同的化学和形态特征，从而为它们提供不同的体内毒性。这里，我们建议评估和比较从 CoCrMo 锥体和骨水泥 - 杆接口在体内释放的颗粒的特征，与来自髋关节轴承的碎片相比，这些颗粒受到的关注较少。该研究使用最先进的表征技术，通过酶处理，详细了解从修复后的髋关节置换术的磨损和腐蚀薄片中释放出的颗粒的大小、形态、成分和化学性质。相分析确定了 Cr₂ O ₃纳米粒子从锥体和水泥杆界面释放，其组成不随来源或粒子形态变化。尺寸分布表明，与源自相应锥体的颗粒相比，从茎中释放出的颗粒明显更小。研究表明，发生在锥形和阀杆界面的摩擦腐蚀过程都会导致 Cr ₂ O ₃纳米颗粒的形成。