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Efficient Chemoenzymatic Synthesis of N-Glycans with a β1,4-Galactosylated Bisecting GlcNAc Motif.
ChemBioChem ( IF 2.6 ) Pub Date : 2020-06-28 , DOI: 10.1002/cbic.202000268 Michael Weiss 1 , Dimitri Ott 1 , Theodoros Karagiannis 1 , Markus Weishaupt 1 , Mathäus Niemietz 1 , Steffen Eller 1 , Marie Lott 1 , Mónica Martínez-Orts 2 , Ángeles Canales 2 , Nahid Razi 3 , James C Paulson 3 , Carlo Unverzagt 1
ChemBioChem ( IF 2.6 ) Pub Date : 2020-06-28 , DOI: 10.1002/cbic.202000268 Michael Weiss 1 , Dimitri Ott 1 , Theodoros Karagiannis 1 , Markus Weishaupt 1 , Mathäus Niemietz 1 , Steffen Eller 1 , Marie Lott 1 , Mónica Martínez-Orts 2 , Ángeles Canales 2 , Nahid Razi 3 , James C Paulson 3 , Carlo Unverzagt 1
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From analytical oddity to conformational study. A rare N‐glycan with a galactosylated bisecting GlcNAc present in human serum immunoglobulin (IgG1) was obtained by chemoenzymatic synthesis from A and derivatized with a lanthanide tag (B). Paramagnetic NMR studies revealed a conformational behavior deviating from that of the non‐bisected biantennary N‐glycan.
中文翻译：
用β1,4-半乳糖基化的二等分GlcNAc基序进行N-聚糖的高效化学合成。
从分析怪异到构象研究。人血清免疫球蛋白（IgG1）中存在半乳糖化二等分GlcNAc的稀有N-聚糖是通过化学酶法从A中获得的，并用镧系元素标记（B）衍生化。顺磁NMR研究表明其构象行为与未等分的双天线N-聚糖不同。
更新日期：2020-06-28
中文翻译：
用β1,4-半乳糖基化的二等分GlcNAc基序进行N-聚糖的高效化学合成。
从分析怪异到构象研究。人血清免疫球蛋白（IgG1）中存在半乳糖化二等分GlcNAc的稀有N-聚糖是通过化学酶法从A中获得的，并用镧系元素标记（B）衍生化。顺磁NMR研究表明其构象行为与未等分的双天线N-聚糖不同。
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