A Graphdiyne Oxide-Based Iron Sponge with Photothermally Enhanced Tumor-Specific Fenton Chemistry.,Advanced Materials

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A Graphdiyne Oxide-Based Iron Sponge with Photothermally Enhanced Tumor-Specific Fenton Chemistry.
Advanced Materials ( IF 27.4 ) Pub Date : 2020-06-28 , DOI: 10.1002/adma.202000038
Huan Min _{1,

2} , Yingqiu Qi ₃ , Yinlong Zhang ₂ , Xuexiang Han ₂ , Keman Cheng ₂ , Ying Liu _{2,

4} , Huibiao Liu ₅ , Jianshe Hu ₁ , Guangjun Nie _{2,

4,

6} , Yiye Li _{2,

4}

Affiliation

Fenton reaction‐mediated oncotherapy is an emerging strategy which uses iron ions to catalytically convert endogenous hydrogen peroxide into hydroxyl radicals, the most reactive oxygen species found in biology, for efficient cancer therapy. However, Fenton reaction efficiency in tumor tissue is typically limited due to restrictive conditions. One strategy to overcome this obstacle is to increase the temperature specifically at the tumor site. Herein, a tumor‐targeting iron sponge (TTIS) nanocomposite based on graphdiyne oxide, which has a high affinity for iron is described. TTIS can accumulate in tumor tissue by decoration with a tumor‐targeting polymer to enable tumor photoacoustic and magnetic resonance imaging. With its excellent photothermal conversion efficiency (37.5%), TTIS is an efficient photothermal therapy (PTT) agent. Moreover, the heat produced in the process of PTT can accelerate the release of iron ions from TTIS and simultaneously enhance the efficiency of the Fenton reaction, thus achieving a combined PTT and Fenton reaction‐mediated cancer therapy. This work introduces a graphdiyne oxide‐based iron sponge that exerts an enhanced antitumor effect through PTT and Fenton chemistry.

中文翻译：

基于石墨二炔氧化物的铁海绵，具有光热增强的肿瘤特定Fenton化学作用。

Fenton反应介导的肿瘤疗法是一种新兴策略，利用铁离子将内源性过氧化氢催化转化为羟基自由基，这是生物学中发现的最具活性的氧，可用于有效的癌症治疗。然而，由于限制性条件，肿瘤组织中的芬顿反应效率通常受到限制。克服这一障碍的一种策略是专门提高肿瘤部位的温度。本文描述了一种基于石墨二炔氧化物的靶向肿瘤的海绵铁（TTIS）纳米复合材料，它对铁具有很高的亲和力。TTIS可以通过用靶向肿瘤的聚合物进行修饰来在肿瘤组织中积累，从而实现肿瘤的光声和磁共振成像。TTIS具有出色的光热转化效率（37.5％），是一种有效的光热疗法（PTT）剂。此外，PTT过程中产生的热量可以加速TTIS中铁离子的释放，同时提高Fenton反应的效率，从而实现PTT和Fenton反应介导的癌症联合治疗。这项工作引入了一种基于氧化石墨烯的铁海绵，它通过PTT和Fenton化学作用发挥了增强的抗肿瘤作用。

更新日期：2020-08-04

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