Bioresorbable, Wireless, Passive Sensors as Temporary Implants for Monitoring Regional Body Temperature.,Advanced Healthcare Materials

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Bioresorbable, Wireless, Passive Sensors as Temporary Implants for Monitoring Regional Body Temperature.
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-06-29 , DOI: 10.1002/adhm.202000942
Di Lu ₁ , Ying Yan ₂ , Raudel Avila _{3,

4} , Irawati Kandela _{5,

6} , Iwona Stepien _{5,

6} , Min-Ho Seo ₁ , Wubin Bai ₁ , Quansan Yang ₁ , Chenhang Li _{3,

4} , Chad R Haney _{6,

7} , Emily A Waters _{6,

7} , Matthew R MacEwan ₂ , Yonggang Huang _{3,

4} , Wilson Z Ray ₂ , John A Rogers ₁

Affiliation

Measurements of regional internal body temperatures can yield important information in the diagnosis of immune response‐related anomalies, for precisely managing the effects of hyperthermia and hypothermia therapies and monitoring other transient body processes such as those associated with wound healing. Current approaches rely on permanent implants that require extraction surgeries after the measurements are no longer needed. Emerging classes of bioresorbable sensors eliminate the requirements for extraction, but their use of percutaneous wires for data acquisition leads to risks for infection at the suture site. As an alternative, a battery‐free, wireless implantable device is reported here, which is constructed entirely with bioresorbable materials for monitoring regional internal body temperatures over clinically relevant timeframes. Ultimately, these devices disappear completely in the body through natural processes. In vivo demonstrations indicate stable operation as subcutaneous and intracranial implants in rat models for up to 4 days. Potential applications include monitoring of healing cascades associated with surgical wounds, recovery processes following internal injuries, and the progression of thermal therapies for various conditions.

中文翻译：

生物可吸收，无线，被动式传感器作为用于监测局部体温的临时植入物。

区域内部体温的测量可以在诊断与免疫反应相关的异常中提供重要信息，以精确管理高温和低温疗法的效果并监测其他短暂的身体过程，例如与伤口愈合相关的过程。当前的方法依赖于永久性植入物，该永久性植入物在不再需要测量之后需要提取手术。新兴类别的生物可吸收传感器消除了对提取的要求，但是使用经皮导线进行数据采集会导致缝合部位感染的风险。作为替代方案，此处报告了一种无电池的无线植入式设备，该设备完全由可生物吸收的材料制成，可在临床相关的时间范围内监控局部体内温度。最终，这些设备通过自然过程完全消失在体内。体内实验表明，在大鼠模型中，皮下和颅内植入物可稳定运行长达4天。潜在的应用包括监测与手术伤口相关的愈合过程，内伤后的恢复过程以及各种条件下的热疗进展。

更新日期：2020-08-19

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