The endoplasmic reticulum-associated degradation (ERAD) pathway eliminates misfolded proteins. The Hrd1 complex represents the main gate mediating retrotranslocation of ER luminal misfolded (ERAD-L) substrates to the cytosol. A recent cryo-electron microscopy (cryo-EM) study by Wu et al. unveils the structural features of active Hrd1, providing mechanistic insights into the movement of proteins directed for degradation across ER membranes.

中文翻译：

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ER相关蛋白质在原子分辨率下的降解。

内质网相关降解（ERAD）途径消除了错误折叠的蛋白质。Hrd1复合体代表介导ER腔错折叠（ERAD-L）底物向细胞质逆转的主闸门。Wu等人最近的低温电子显微镜（cryo-EM）研究。揭示了活性Hrd1的结构特征，提供了针对直接穿过ER膜降解的蛋白质运动的机械见解。