当前位置: X-MOL 学术Mater. Today Commun. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Excellent relaxivity and X-ray attenuation combo properties of Fe3O4@Au CSNPs produced via Rapid sonochemical synthesis for MRI and CT imaging
Materials Today Communications ( IF 3.7 ) Pub Date : 2020-06-29 , DOI: 10.1016/j.mtcomm.2020.101368
Mohammed Ali Dheyab , Azlan Abdul Aziz , Mahmood S Jameel , Osama Abu Noqta , Pegah Moradi Khaniabadi , Baharak Mehrdel

Core@shell nanoparticles (Fe3O4@Au CSNPs) have multiple functions obtained in one stable entity and thus have been extensively investigated. Fe3O4 NPs have unique superparamagnetic properties which allow for their application in different fields, and Au NPs stand out in biomedical applications because of their chemical stability, oxidation resistance and high-quality intrinsic optical properties. Combining Fe3O4 and Au NPs in one core@shell nanostructure is a promising strategy for diagnostic biomedical applications. However, the conventional direct methods for Fe3O4@Au CSNP synthesis are laborious and time consuming. Therefore, this study presents a facile and rapid sonochemical technique of synthesising Fe3O4@Au CNPs with excellent physicochemical properties for magnetic resonance imaging (MRI) and computed tomography (CT) scan. A Vibra Cell ultrasonic solid horn with a tip size of ½ inch, 20 kHz frequency and power output of 750 W were used, and the synthesis is achieved in just 10 min. Several techniques were used to characterise the Fe3O4@Au CSNPs and confirmed their average size of 21 nm and the formation of spherical Au shell on the Fe3O4 core. The Fe3O4@Au CNPs showed good biocompatibility and great potential as a dual-mode contrast agent for MRI/CT imaging. The transverse relaxivity values and X-ray attenuation of the as-synthesised NPs (222.28 mM−1s−1 and HU = 418) are greater than those of NPs prepared using conventional methods and commercial NPs. This work reveals considerable progress on Fe3O4@Au CSNPs by providing a facile and rapid method to synthesise high-quality Au-coated Fe3O4 NPs.



中文翻译:

通过快速声化学合成制备的用于MRI和CT成像的Fe 3 O 4 @Au CSNP具有出色的弛豫性和X射线衰减组合特性

核壳纳米粒子(Fe 3 O 4 @Au CSNP)在一个稳定的实体中具有多种功能,因此已得到广泛研究。Fe 3 O 4 NP具有独特的超顺磁性质,可用于不同领域,而Au NP由于其化学稳定性,抗氧化性和高质量的固有光学性能而在生物医学应用中脱颖而出。在一个核壳纳米结构中结合Fe 3 O 4和Au NP是一种有前景的诊断生物医学应用策略。然而,常规的直接方法Fe 3 O 4@Au CSNP合成费力且费时。因此,本研究提出了一种简便,快速的声化学技术,用于合成具有优异物理化学性质的Fe 3 O 4 @Au CNP,用于磁共振成像(MRI)和计算机断层扫描(CT)扫描。使用了具有½英寸尖端尺寸,20 kHz频率和750 W功率输出的Vibra Cell超声固体喇叭,并且仅在10分钟内即可完成合成。使用了几种技术来表征Fe 3 O 4 @Au CSNP,并确认了它们的平均大小为21 nm,并在Fe 3 O 4核上形成了球形Au壳。铁3 O 4@Au CNPs具有良好的生物相容性,作为MRI / CT成像的双模造影剂具有巨大的潜力。合成后的NP的横向弛豫值和X射线衰减(222.28 mM -1 s -1和HU = 418)大于使用常规方法和商业NP制备的NP。这项工作揭示了Fe 3 O 4 @Au CSNPs的重要进展,因为它提供了一种简便而快速的方法来合成高质量的Au包覆的Fe 3 O 4 NPs。

更新日期:2020-06-29
down
wechat
bug