OBJECTIVE Phasic bursts of beta band synchronisation have been linked to motor impairment in Parkinson's disease (PD). However, little is known about what terminates bursts. METHODS We used the Hilbert-Huang transform to investigate beta bursts in the local field potential recorded from the subthalamic nucleus in nine patients with PD on and off levodopa. RESULTS The sharpness of the beta waveform extrema fell as burst amplitude dropped. Conversely, an index of phase slips between waveform extrema, and the power of concurrent theta activity increased as burst amplitude fell. Theta activity was also increased on levodopa when beta bursts were attenuated. These phenomena were associated with reduction in coupling between beta phase and high gamma activity amplitude. We discuss how these findings may suggest that beta burst termination is associated with relative desynchronization of the beta drive, increase in competing theta activity and increased phase slips in the beta activity. CONCLUSIONS We characterise the dynamical nature of beta bursts, thereby permitting inferences about underlying activities and, in particular, about why bursts terminate. SIGNIFICANCE Understanding the dynamical nature of beta bursts may help point to interventions that can cause their termination and potentially treat motor impairment in PD.

中文翻译：

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人丘脑底核中随β爆发演化的波形变化

目的 β 波段同步的阶段性爆发与帕金森病 (PD) 的运动障碍有关。然而，人们对终止爆发的原因知之甚少。方法 我们使用 Hilbert-Huang 变换来研究 9 名患有左旋多巴和非左旋多巴的 PD 患者的丘脑底核记录的局部场电位中的 β 爆发。结果 β 波形极值的锐度随着突发幅度的下降而下降。相反，波形极值之间的相位滑移指数和同时发生的 theta 活动的功率随着突发幅度的下降而增加。当β爆发减弱时，左旋多巴的θ活性也增加。这些现象与 β 相和高伽马活动幅度之间的耦合减少有关。我们讨论了这些发现如何表明 beta 爆发终止与 beta 驱动器的相对不同步、竞争性 theta 活动的增加和 beta 活动中的相位滑移增加有关。结论 我们描述了 β 爆发的动态特性，从而可以推断出潜在的活动，特别是关于爆发终止的原因。意义 了解 β 爆发的动力学性质可能有助于指出可能导致其终止并可能治疗 PD 运动障碍的干预措施。关于为什么爆发终止。意义 了解 β 爆发的动力学性质可能有助于指出可能导致其终止并可能治疗 PD 运动障碍的干预措施。关于为什么爆发终止。意义 了解 β 爆发的动力学性质可能有助于指出可能导致其终止并可能治疗 PD 运动障碍的干预措施。