The current global pandemic COVID-19 caused by the SARS-CoV-2 virus has already inflicted insurmountable damage both to the human lives and global economy. There is an immediate need for identification of effective drugs to contain the disastrous virus outbreak. Global efforts are already underway at a war footing to identify the best drug combination to address the disease. In this review, an attempt has been made to understand the SARS-CoV-2 life cycle, and based on this information potential druggable targets against SARS-CoV-2 are summarized. Also, the strategies for ongoing and future drug discovery against the SARS-CoV-2 virus are outlined. Given the urgency to find a definitive cure, ongoing drug repurposing efforts being carried out by various organizations are also described. The unprecedented crisis requires extraordinary efforts from the scientific community to effectively address the issue and prevent further loss of human lives and health.

中文翻译：

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COVID-19 疗法的药物靶点：正在进行的全球努力

当前由 SARS-CoV-2 病毒引起的全球大流行 COVID-19 已经对人类生活和全球经济造成了无法克服的损害。迫切需要确定有效的药物来控制灾难性的病毒爆发。全球正在努力寻找解决该疾病的最佳药物组合。在这篇综述中，试图了解 SARS-CoV-2 的生命周期，并基于这些信息总结了针对 SARS-CoV-2 的潜在药物靶点。此外，还概述了针对 SARS-CoV-2 病毒正在进行和未来的药物发现策略。鉴于寻找最终治愈方法的紧迫性，还描述了各种组织正在进行的药物再利用工作。