In the present investigation an attempt was made to evaluate the potential of agnucastoside C (ACC), isolated from the leaves of Moringa oleifera in ameliorating thyrotoxicosis, hepatic lipid peroxidation (LPO) and hyperglycemia in female mice. L-thyroxine (L-T4) at 0.5 mg/kg/d was administered through intra-peritoneal route for 15 consecutive days to induce thyrotoxicosis and then the effects of three different doses (10, 20 and 30 mg/kg body weight) of the isolated ACC for 21 days were investigated on the changes in serum thyroid hormones, insulin, glucose, different lipids; hepatic lipid peroxidation, enzymatic antioxidants such as superoxide dismutase, catalase and glutathione peroxidase, advanced oxidation protein products, reduced glutathione and in lipid peroxides. Following the administration of L-T4, serum T3, T4, insulin, glucose levels and the tissue LPO were increased with a decrease in serum thyroid stimulating hormone and antioxidative enzymes. However, administration of the test compound to hyperthyroid animals significantly decreased the levels of thyroid hormones, glucose and lipid peroxidation and normalized the concentration of insulin and tissue antioxidants, suggesting its antithyroid, antihyperglycemic and antiperoxidative potential. The T4-induced adverse effects on liver histology were also abolished. These findings suggest the possible use of the test compound in ameliorating thyrotoxicosis. ACC exhibited antithyroidic, antihypoglycemic, antioxidative and insulin normalizing activities.

中文翻译：

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从辣木中分离出的苦瓜苷C改善了雌性小鼠的甲状腺毒症和肝脏异常

在本研究中，人们尝试评估从辣木叶中分离出的金银花苷C（ACC）在改善雌性小鼠的甲状腺毒性，肝脂质过氧化（LPO）和高血糖症方面的潜力。连续15天通过腹膜内给药0.5 mg / kg / d的L-甲状腺素（L-T4）诱发甲状腺毒症，然后服用三种不同剂量（10、20和30 mg / kg体重）的甲状腺素分离21天的ACC，观察血清甲状腺激素，胰岛素，葡萄糖，不同脂质的变化。肝脂质过氧化，酶促抗氧化剂（如超氧化物歧化酶，过氧化氢酶和谷胱甘肽过氧化物酶），高级氧化蛋白产物，还原型谷胱甘肽和脂质过氧化物。服用L-T4，血清T3，T4，胰岛素后，随着血清甲状腺刺激激素和抗氧化酶的降低，葡萄糖水平和组织LPO升高。但是，向甲状腺功能亢进的动物给药该测试化合物可显着降低甲状腺激素，葡萄糖和脂质过氧化的水平，并使胰岛素和组织抗氧化剂的浓度正常化，表明其具有抗甲状腺，降血糖和抗过氧化的潜力。T4诱导的对肝脏组织学的不良影响也被消除。这些发现表明该测试化合物可用于改善甲状腺毒症。ACC表现出抗甲状腺，抗降血糖，抗氧化和胰岛素正常化的作用。向甲状腺功能亢进的动物施用测试化合物可显着降低甲状腺激素，葡萄糖和脂质过氧化的水平，并使胰岛素和组织抗氧化剂的浓度正常化，表明其具有抗甲状腺，降血糖和抗过氧化的潜力。T4诱导的对肝脏组织学的不良影响也被消除。这些发现表明该测试化合物可用于改善甲状腺毒症。ACC表现出抗甲状腺，抗降血糖，抗氧化和胰岛素正常化的作用。向甲状腺功能亢进的动物施用测试化合物可显着降低甲状腺激素，葡萄糖和脂质过氧化的水平，并使胰岛素和组织抗氧化剂的浓度正常化，表明其具有抗甲状腺，降血糖和抗过氧化的潜力。T4诱导的对肝脏组织学的不良影响也被消除。这些发现表明该测试化合物可用于改善甲状腺毒症。ACC表现出抗甲状腺，抗降血糖，抗氧化和胰岛素正常化的作用。T4诱导的对肝脏组织学的不良影响也被消除。这些发现表明该测试化合物可用于改善甲状腺毒症。ACC表现出抗甲状腺，抗降血糖，抗氧化和胰岛素正常化的作用。T4诱导的对肝脏组织学的不良影响也被消除。这些发现表明该测试化合物可用于改善甲状腺毒症。ACC表现出抗甲状腺，抗降血糖，抗氧化和胰岛素正常化的作用。