Aryl Phosphonate-Directed Ortho C–H Borylation: Rapid Entry into Highly-Substituted Phosphoarenes,Journal of the American Chemical Society

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Aryl Phosphonate-Directed Ortho C–H Borylation: Rapid Entry into Highly-Substituted Phosphoarenes
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2020-06-27 , DOI: 10.1021/jacs.0c04159
Feiyang Xu _{1,

2} , Olivia M Duke ₁ , Daniel Rojas ₁ , Hanka M Eichelberger _{1,

2} , Raphael S Kim ₁ , Timothy B Clark ₂ , Donald A Watson ₁

Affiliation

Phosphonate-directed ortho C-H borylation of aromatic phosphonates is reported. Using simple starting materials and com-mercially accessible catalysts, this method provides steady access to ortho-phosphonate aryl boronic esters bearing pendant functionality and flexible substitution patterns. These products serve as flexible precursors for a variety of highly-substituted phosphoarenes, and in situ downstream functionalization of the products is described.

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