Cortical gyrification has been found to decrease due to aging, but thus far this has only been examined in cross-sectional samples. Interestingly, the topography of these age-related differences in gyrification follow a distinct gradient along the cortex relative to age effects on cortical thickness, likely suggesting a different underlying neurobiological mechanism. Here I examined several aspects of gyrification in an accelerated longitudinal dataset of 280 healthy adults aged 45-92 with an interval between first and last MRI session of up to 10 years (total of 815 MRI sessions). Results suggest that age changes in sulcal morphology underlie these changes in gyrification.

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与年龄相关的皮质回旋减量：来自加速纵向数据集的证据

已经发现皮质回旋由于老化而减少，但是迄今为止仅在横截面样品中进行了检验。有趣的是，这些年龄相关的回旋变化的地形相对于年龄对皮质厚度的影响沿皮质沿着明显的梯度变化，这可能暗示了不同的潜在神经生物学机制。在这里，我研究了280个45-92岁的健康成年人的纵向纵向数据集，其中第一次和最后一次MRI会话之间的间隔长达10年（总共815 MRI会话），在加速纵向数据集中检查了回旋的几个方面。结果表明，沟渠形态的年龄变化是这些回旋变化的基础。