Introduction

The use of enzymes in various industries has been prevalent for centuries. However, their potency as therapeutics remained latent until the late 1950 s, when scientists finally realized the gold mine they were sitting on. Enzyme therapy has seen rapid development over the past few decades and has been widely used for the therapy of myriad diseases, including lysosomal storage disorders, cancer, Alzheimer’s disease, irritable bowel syndrome, exocrine pancreatic insufficiency, and hyperuricemia. Enzymes are also used for wound healing, the treatment of microbial infections, and gene therapy.

Areas covered

This is a comprehensive review of the therapeutic use of enzymes that can act as a guidepost for researchers and academicians and presents a general overview of the developments in enzyme therapy over the years, along with updates on recent advancements in enzyme therapy research.

Expert opinion

Although enzyme therapy is immensely beneficial and induces little auxiliary damage, it has several drawbacks, ranging from high cost, low stability, low production, and hyperimmune responses to the failure to cure a variety of the problems associated with a disease. Further fine-tuning and additional clinical efficacy studies are required to establish enzyme therapy as a forerunner to catalyzing a healthy society.

中文翻译：

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酶疗法：催化健康社会的先驱？

介绍

几个世纪以来，酶在各种工业中的使用很普遍。但是，直到1950年代后期，科学家们终于意识到他们所坐的金矿之后，它们作为治疗剂的潜力仍然存在。在过去的几十年中，酶疗法发展迅速，已广泛用于治疗多种疾病，包括溶酶体贮积病，癌症，阿尔茨海默氏病，肠易激综合征，外分泌型胰腺功能不全和高尿酸血症。酶还用于伤口愈合，微生物感染的治疗和基因治疗。

覆盖区域

这是对酶治疗用途的全面综述，可以作为研究人员和学者的指南，并概述了近年来酶治疗的发展，以及酶治疗研究的最新进展。

专家意见

尽管酶疗法非常有益并且几乎不会引起辅助损害，但是它具有一些缺点，包括高成本，低稳定性，低产量和对无法治愈与疾病相关的各种问题的过度免疫反应。需要进一步的微调和附加的临床功效研究，以建立酶疗法作为促进健康社会的先驱。