Streptococci and the complement system: interplay during infection, inflammation and autoimmunity,FEBS Letters

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Streptococci and the complement system: interplay during infection, inflammation and autoimmunity
FEBS Letters ( IF 3.0 ) Pub Date : 2020-08-01 , DOI: 10.1002/1873-3468.13872
Shahan Syed ₁ , Larisa Viazmina ₁ , Riccardo Mager ₂ , Seppo Meri _{1,

2} , Karita Haapasalo ₁

Affiliation

Streptococci are a broad group of Gram-positive bacteria. This genus includes various human pathogens causing significant morbidity and mortality. Two of the most important human pathogens are Streptococcus pneumoniae (pneumococcus) and Streptococcus pyogenes (group A streptococcus or GAS). Streptococcal pathogens have evolved to express virulence factors that enable them to evade complement-mediated attack. These include factor H binding M (S. pyogenes) and pneumococcal surface protein C (PspC) (S. pneumoniae) proteins. In addition, S. pyogenes and S. pneumoniae express cytolysins (streptolysin and pneumolysin), which are able to destroy host cells. Sometimes the interplay between streptococci, the complement and antistreptococcal immunity may lead to an excessive inflammatory response or autoimmune disease. Understanding the fundamental role of the complement system in microbial clearance and the bacterial escape mechanisms is of paramount importance for understanding microbial virulence, in general, and, the conversion of commensals to pathogens, more specifically. Such insights may help to identify novel antibiotic and vaccine targets in bacterial pathogens to counter their growing resistance to commonly used antibiotics.

中文翻译：

链球菌和补体系统：感染、炎症和自身免疫过程中的相互作用

链球菌是一大类革兰氏阳性菌。该属包括导致显着发病率和死亡率的各种人类病原体。两种最重要的人类病原体是肺炎链球菌（肺炎球菌）和化脓性链球菌（A 组链球菌或 GAS）。链球菌病原体已经进化为表达毒力因子，使它们能够逃避补体介导的攻击。这些包括结合 H 因子的 M（化脓性链球菌）和肺炎球菌表面蛋白 C（PspC）（肺炎链球菌）蛋白。此外，化脓性链球菌和肺炎链球菌表达能够破坏宿主细胞的溶细胞素（链球菌溶血素和肺炎链球菌溶血素）。有时链球菌、补体和抗链球菌免疫之间的相互作用可能导致过度的炎症反应或自身免疫性疾病。了解补体系统在微生物清除和细菌逃逸机制中的基本作用对于了解微生物毒力（一般而言）以及共生物向病原体的转化至关重要。这些见解可能有助于确定细菌病原体中的新型抗生素和疫苗靶标，以应对它们对常用抗生素日益增长的耐药性。

更新日期：2020-08-01

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