The tropical estuarine guppy Poecilia vivipara was used to address fish early life stage toxicity caused by the antifouling contaminant tributyltin. Six‐day‐old P. vivipara were exposed for 7 d to control water and waterborne tributyltin at 15.8, 83.8, 716, and 818 ng tin (Sn) L^–1. After exposure, swimming, feeding, growth, and eye histological endpoints were evaluated. Histopathological analysis of the retinal pigment epithelium (RPE) indicated alterations in pigment positioning at all tributyltin concentrations. A dose‐dependent increase in photoreceptor layer disorganization and iris melanin hyperpigmentation was verified, and high frequencies of RPE invaginations and iris epithelial cell atrophy were observed even at the lowest exposure concentration of 15.8 ng Sn L^–1. At the highest exposure level (818 ng Sn L^–1) fish also presented reductions in swimming speed, swimming resistance, daily capture of Artemia nauplii, and growth in weight of 85, 60, 33, and 56% relative to controls, respectively. This association between retinal histopathology and reduced swimming and foraging behavior can reduce recruitment to the adult population. Environ Toxicol Chem 2020;39:1953–1963. © 2020 SETAC

中文翻译：

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三丁基锡在热带孔雀鱼Poecilia vivipara中的组织学和行为毒性。

热带河口孔雀鱼Poecilia vivipara用于解决鱼的生命早期毒性，该毒性是由防污污染物三丁基锡造成的。六天大的比邻疟原虫暴露7 d，以控制水和水性三丁基锡分别为15.8、83.8、716和818 ng锡（Sn）L ^–1。暴露后，评估游泳，喂养，生长和眼睛组织学终点。视网膜色素上皮（RPE）的组织病理学分析表明，在所有三丁基锡浓度下，色素位置发生变化。证实了剂量依赖性光感受器层紊乱和虹膜黑色素过度色素沉着的增加，即使在最低暴露浓度为15.8 ng Sn L ^{–1的情况下，}也观察到高频率的RPE侵染和虹膜上皮细胞萎缩。在最高暴露水平（818 ng Sn L ^–1）下，鱼的游泳速度，游泳阻力和每天捕获的卤虫也降低了无节幼体，相对于对照，体重增长分别为85％，60％，33％和56％。视网膜组织病理学与减少的游泳和觅食行为之间的这种关联可以减少成年人的募集。2020年《环境毒理学》； 39：1953-1963。©2020 SETAC