European Journal of Medicinal Chemistry ( IF 6.0 ) Pub Date : 2020-06-28 , DOI: 10.1016/j.ejmech.2020.112506 Yu Han 1 , Wei Dong 1 , Qunqun Guo 2 , Xiufen Li 1 , Longjiang Huang 3
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With some indoles and azaindoles being successfully developed as anticancer drugs, the design and synthesis of indole and azaindole derivatives with remarkable antitumor activity has received increasing attention and significant progress has been made. This paper reviews the recent progress in the study of tumorigenesis, mechanism of actions and structure activity relationships about anticancer indole and azindole derivatives. Combining structure activity relationships and molecular targets-related knowledge, this review will help researchers design more effective, safe and cost-effective anticancer indoles and azindoles agents.
中文翻译：
吲哚和氮杂吲哚支架在抗肿瘤药物开发中的重要性。
随着一些吲哚和氮杂吲哚作为抗癌药物的成功开发，具有显着抗肿瘤活性的吲哚和氮杂吲哚衍生物的设计和合成受到了越来越多的关注，并取得了重大进展。本文综述了有关抗癌吲哚和吲哚衍生物的肿瘤发生，作用机理和结构活性关系的最新研究进展。结合结构活性关系和与分子靶标相关的知识，本综述将帮助研究人员设计更有效，安全和具有成本效益的抗癌吲哚和吲哚类药物。
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