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Tunable electrochemical synthesis of 3D nucleated microparticles like Cu-BTC MOF-carbon nanotubes composite: Enzyme free ultrasensitive determination of glucose in a complex biological fluid
Electrochimica Acta ( IF 5.5 ) Pub Date : 2020-06-28 , DOI: 10.1016/j.electacta.2020.136673
P. Arul , N.S.K. Gowthaman , S. Abraham John , Masato Tominaga

The present study describes the fabrication of 3D nucleated microparticles like Cu-MOF (MPsLCu-MOF)-SWCNTs composite on glassy carbon electrode (GCE) by electrodeposition and applied as a sensor for the sensitive determination of glucose in human saliva samples. First, SWCNTs were deposited on GCE by potential cycling between 0.0 V to -1.0 V and then, Cu-MOF was electrodeposited on SWCNTs modified GCE using a ligand, 1,3,5-benzene tricarboxylic acid (BTC), triethylamine hydrochloride and copper salt. The SEM studies showed the formation of MPsLCu-MOF on SWCNTs as well as on bare GCE with 1 μm size. The impedance studies showed that the heterogeneous electron transfer rate constant of [Fe(CN)6]3-/4- was higher at SWCNTs-MPsLCu-MOF than bare GCE and SWCNTs and MPsLCu-MOF modified GCEs. Then, the composite electrode was utilized for non-enzymatic detection of glucose. The SWCNTs-MPsLCu-MOF modified electrode showed a well-defined sharp oxidation peak at 0.45 V with enhanced current than bare GCE and SWCNTs and MPsLCu-MOF modified GCEs. As the concentration of glucose increases from 10-160 × 10-6 M, the oxidation current also increases without shifting its oxidation potential. The present composite modified electrode was also used to determine glucose in the linear range of 20 × 10-9 M to 80 × 10-6 M by amperometry with a LOD of 1.72 × 10-9 M (S/N=3) and a superior sensitivity of 573 μA mM−1 cm−2. Finally, the composite fabricated electrode was exploited for real-time analysis of glucose in human saliva samples and satisfactory results were obtained.



中文翻译:

可调谐电化学合成3D有核微粒,例如Cu-BTC MOF-碳纳米管复合材料:复杂生物流体中葡萄糖的无酶超灵敏测定

本研究描述了通过电沉积在玻碳电极(GCE)上制备3D有核微粒,如Cu-MOF(MPsLCu-MOF)-SWCNTs复合材料,并用作敏感测定人唾液样品中葡萄糖的传感器。首先,通过在0.0 V至-1.0 V之间的电势循环将SWCNT沉积在GCE上,然后,使用配体,1,3,5-苯三羧酸(BTC),三乙胺盐酸盐和铜将Cu-MOF电沉积在SWCNT修饰的GCE上盐。SEM研究表明,MPsLCu-MOF在SWCNT以及尺寸为1μm的裸GCE上形成。阻抗研究表明,[Fe(CN)6 ] 3- / 4-的异质电子传递速率常数SWCNTs-MPsLCu-MOF比裸GCE和SWCNTs和MPsLCu-MOF修饰的GCE高。然后,将复合电极用于葡萄糖的非酶检测。与裸GCE和SWCNTs和MPsLCu-MOF修饰的GCE相比,SWCNTs-MPsLCu-MOF修饰的电极在0.45 V处显示出明确定义的尖锐氧化峰,并具有增强的电流。随着葡萄糖浓度从10-160×10 -6 M增加,氧化电流也增加而不改变其氧化电位。本复合修饰电极还用于通过安培法在20×10 -9 M至80×10 -6 M的线性范围内测定葡萄糖,LOD为1.72×10 -9 M(S / N = 3), 573μAmM -1  cm的出色灵敏度−2。最后,将该复合电极用于人唾液样品中葡萄糖的实时分析,并获得满意的结果。

更新日期:2020-07-03
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