Liver X receptors (LXRs) are transcription factors from the nuclear receptor family that can be pharmacologically activated by high-affinity agonists. LXR activation exerts a combination of metabolic and anti-inflammatory actions that result in the modulation of immune responses and in the amelioration of inflammatory disorders. In addition, LXR agonists modulate the metabolism of infected cells and limit the infectivity and/or growth of several pathogens. This review gives an overview of the recent advances in understanding the complexity of the mechanisms through which the LXR pathway controls inflammation and host–cell pathogen interaction.

中文翻译：

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整合肝脏 X 受体在炎症和感染中的作用：机制和结果。

肝 X 受体 (LXR) 是来自核受体家族的转录因子，可以通过高亲和力激动剂在药理学上激活。LXR 激活发挥代谢和抗炎作用的组合，导致免疫反应的调节和炎症疾病的改善。此外，LXR 激动剂调节受感染细胞的代谢并限制几种病原体的传染性和/或生长。本综述概述了在理解 LXR 通路控制炎症和宿主细胞病原体相互作用机制的复杂性方面的最新进展。