Abstract

Four new sesquiterpenoids, artemyrianins A–D (1–4), and three new norlignans, artemyrianins E–G (5–7), together with five known compounds (8–12), were isolated from the aerial parts of Artemisia myriantha (Asteraceae). The new compounds were established by spectroscopic data analyses (HRMS, IR, 1D and 2D NMR), and their absolute configurations were confirmed by the single-crystal X-ray diffraction or ECD calculations. The isolates showed cytotoxicity against HepG2 cells with IC₅₀ values ranging from 33.3 to 145.2 μM.

Graphic Abstract

中文翻译：

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青蒿的青蒿素股份公司及其对HepG2细胞的细胞毒性。

摘要

四个新的倍半萜类，artemyrianins A-d（1 - 4），和三个新norlignans，artemyrianins E-G（5 - 7），加上5种已知化合物（8 - 12），从地上部分分离蒿myriantha（菊科）。通过光谱数据分析（HRMS，IR，1D和2D NMR）建立了新化合物，并通过单晶X射线衍射或ECD计算证实了它们的绝对构型。菌株显示针对HepG2细胞的细胞毒性与IC _50个值范围为33.3至145.2  μ M.

图形摘要