Our previous studies have been focused on the design, optimization and manufacture of a partially resorbable composite bone plate consisting of a poly l-lactic acid matrix reinforced with braided fabrics bioactive glass fibers (PLLA/BG). In the present study, the response of the composite samples, the degradation rate, the inflammatory response, fibrous capsule formation and tissue-implant bonding to the in-vivo environment were assessed via implantation in the rabbit subcutaneous tissue. Despite the presence of both enzymatic degradation and hydrolysis processes within the body, the rate of the molecular weight loss as an indicator of degradation did not show a significant difference with the in-vitro conditions. It was predicted that strength loss would show the same trend since it was a consequence of molecular chain disruption and the loss of molecular weight. Inexistence of chronic inflammation, as confirmed by our previous results on the controlled degradation rate, also showed the maintenance of the physiological pH in the peripheral environment of the implant. Moreover, lack of the fibrous capsule tissue around the implant indicated that the implant was bioactive. In addition, given the composition of the bioactive glass fibers, that could be bonded to soft and hard tissues, tissue bonding with the PLLA/BG composite samples was also observed, thereby confirming the bioactivity and biocompatibility of the proposed bone plate.

我们以前的研究集中在设计，优化和制造部分可吸收的复合骨板，该复合骨板由编织纤维生物活性玻璃纤维（PLLA / BG）增强的聚l-乳酸基质组成。在本研究中，通过在兔皮下组织中植入来评估复合样品的反应，降解率，炎症反应，纤维囊的形成以及组织-植入物对体内环境的结合。尽管体内同时存在酶促降解和水解过程，但作为降解指标的分子量损失率与体外条件没有显着差异。据预测，强度损失将显示出相同的趋势，因为这是分子链断裂和分子量损失的结果。如我们先前关于可控降解速率的结果所证实的，慢性炎症的不存在也显示了植入物周围环境中生理pH的维持。此外，植入物周围缺乏纤维囊组织表明植入物具有生物活性。另外，考虑到可以结合到软组织和硬组织的生物活性玻璃纤维的组成，还观察到了与PLLA / BG复合样品的组织粘合，从而证实了所提出的骨板的生物活性和生物相容性。还表明在植入物的周围环境中维持生理pH。此外，植入物周围缺乏纤维囊组织表明植入物具有生物活性。另外，考虑到可以结合到软组织和硬组织的生物活性玻璃纤维的组成，还观察到了与PLLA / BG复合样品的组织粘合，从而证实了所提出的骨板的生物活性和生物相容性。还表明在植入物的周围环境中维持生理pH。此外，植入物周围缺乏纤维囊组织表明植入物具有生物活性。另外，考虑到可以结合到软组织和硬组织的生物活性玻璃纤维的组成，还观察到了与PLLA / BG复合样品的组织粘合，从而证实了所提出的骨板的生物活性和生物相容性。