This work studied the protective effects of Aspergillus awamori against ochratoxin A (OTA)-induced toxicity in APRI maternal line rabbits. A total number of 48 APRI line weanling rabbits (5 weeks) were divided into 4 groups (12 rabbits each) and fed the basal diet, 30 ppb/kg diet of OTA, 1 g/kg diet of A. awamori, and a mixture of OTA and A. awamori for 8 weeks. OTA reduced the final body weight and weight gain as well as the intestinal villi length and thickness, whereas increased the feed intake and feed conversion ratio. Rabbits fed diets with OTA showed significantly reduced crude protein, lipids, and fibers apparent digestibility coefficients (P < 0.05). The red blood cells and hemoglobin were significantly decreased in the OTA group comparing with the other groups (P < 0.05). The blood total protein and albumin displayed significantly lower levels by OTA than the other groups. In contrast, glucose, aspartate aminotransferase (AST), alkaline phosphatase (ALP), urea, and creatinine levels were significantly increased by OTA (P < 0.05). Phagocytic activity (PA) and phagocytic index (PI) showed significantly (P < 0.05) decreased levels in OTA-contaminated group, while rabbits fed A. awamori significantly showed the highest PA and PI levels (P < 0.05). Dietary A. awamori kept the levels of PA and PI in rabbits fed OTA significantly higher than those fed without A. awamori (P < 0.05) and not significantly different from the control group (P > 0.05). Catalase (CAT) and superoxide dismutase (SOD) displayed significantly lower levels in the OTA group, while malondialdehyde (MDA) was significantly higher than the other groups (P < 0.05). Rabbits fed OTA-contaminated diets displayed significantly lower CAT and SOD and higher MDA than rabbits fed OTA combined with A. awamori (P < 0.05). Our results indicated that dietary A. awamori ameliorated the damage in APRI rabbits fed OTA through alleviation of oxidative stress and immunity.

这项工作研究了泡盛曲霉对 APRI 母系兔赭曲霉毒素 A (OTA) 诱导的毒性的保护作用。将 48 只 APRI 系断奶兔（5 周）分成 4 组（每组 12 只兔），分别饲喂基础日粮、30 ppb/kg OTA 日粮、1 g/kg泡盛曲霉日粮和混合物OTA 和A. awamori 8 周。OTA降低了最终体重和增重以及肠绒毛的长度和厚度，同时增加了采食量和饲料转化率。饲喂OTA日粮的兔子的粗蛋白、脂质和纤维表观消化率系数显着降低（P < 0.05)。OTA 组红细胞和血红蛋白较其他组显着降低（P  < 0.05）。OTA 显示的血液总蛋白和白蛋白水平显着低于其他组。相比之下，OTA 显着增加了葡萄糖、天冬氨酸氨基转移酶 (AST)、碱性磷酸酶 (ALP)、尿素和肌酐水平 ( P  < 0.05)。 OTA污染组的吞噬活性（PA）和吞噬指数（PI）水平显着降低（P < 0.05），而喂食泡盛曲霉的兔子的PA和PI水平显着最高（P  < 0.05）。饮食A. awamori使饲喂 OTA 的兔的 PA 和 PI 水平显着高于未饲喂泡盛曲霉的兔（P  < 0.05），与对照组无显着差异（P  > 0.05）。OTA组过氧化氢酶（CAT）和超氧化物歧化酶（SOD）水平显着低于其他组，而丙二醛（MDA）显着高于其他组（P  < 0.05）。与饲喂 OTA 和泡盛曲霉的兔相比，饲喂 OTA 污染日粮的兔的 CAT 和 SOD 显着降低，MDA 更高（P  < 0.05）。我们的结果表明，日粮A. awamori 通过减轻氧化应激和免疫，改善了喂食 OTA 的 APRI 兔的损伤。