Objective. Motor symptoms are usually asymmetric in Parkinson’s disease (PD), and asymmetry in PD may involve widespread brain areas. We sought to evaluate the effect of asymmetry on the whole brain spontaneous activity using the measure regional homogeneity (ReHo) through resting-state functional MRI. Methods. We recruited 30 PD patients with left onset (LPD), 27 with right side (RPD), and 32 controls with satisfactory data. Their demographic, clinical, and neuropsychological information were obtained. Resting-state functional MRI was performed, and ReHo was used to determine the brain activity. ANCOVA was utilized to analyze between-group differences in ReHo and the associations between abnormal ReHo, and various clinical and neuropsychological variables were explored by Spearman’s correlation. Results. LPD patients had higher ReHo in the right temporal pole than the controls. RPD patients had increased ReHo in the right temporal pole and decreased ReHo in the primary motor cortex and premotor area, compared with the controls. Directly comparing LPD and RPD patients did not show a significant difference in ReHo. ReHo of the right temporal pole was significantly correlated with depression and anxiety in RPD patients. Conclusions. Both LPD and RPD have increased brain activity synchronization in the right temporal pole, and only RPD has decreased brain activity synchronization in the right frontal motor areas. The changed brain activity in the right temporal pole may play a compensatory role for depression and anxiety in PD, and the altered cerebral function in the right frontal motor area in RPD may represent the reorganization of the motor system in RPD.

中文翻译：

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帕金森病发病一侧与脑区域均匀性之间的关系：静息态功能磁共振成像研究。


客观的。帕金森病 (PD) 的运动症状通常是不对称的，并且 PD 的不对称可能涉及广泛的大脑区域。我们试图通过静息态功能 MRI 测量区域均匀性 (ReHo) 来评估不对称性对整个大脑自发活动的影响。方法。我们招募了 30 名左侧发病 (LPD) 的 PD 患者、27 名右侧发病 (RPD) 的 PD 患者和 32 名数据令人满意的对照患者。获得了他们的人口统计、临床和神经心理学信息。进行静息态功能 MRI，并使用 ReHo 来确定大脑活动。利用 ANCOVA 分析 ReHo 的组间差异以及异常 ReHo 之间的关联，并通过 Spearman 相关性探讨各种临床和神经心理学变量。结果。 LPD 患者的右颞极 ReHo 值高于对照组。与对照组相比，RPD 患者右颞极 ReHo 增加，初级运动皮层和前运动区 ReHo 减少。直接比较 LPD 和 RPD 患者的 ReHo 没有显示出显着差异。 RPD 患者右颞极 ReHo 与抑郁和焦虑显着相关。结论。 LPD和RPD都增加了右颞极的大脑活动同步性，只有RPD降低了右额叶运动区的大脑活动同步性。右颞极大脑活动的改变可能对PD抑郁和焦虑起到代偿作用，RPD右额叶运动区大脑功能的改变可能代表RPD运动系统的重组。