Objectives. To observe and analyze the parameters of the sacral reflex and pudendal nerve somatosensory evoked potential (SSEP) in patients with multiple system atrophy (MSA) with respect to factors such as age, disease course, and subtype and provide evidence for the clinical diagnosis of MSA. Materials and Methods. A total of 51 MSA patients and 30 healthy controls were selected from the First Affiliated Hospital of Wenzhou Medical University from May 2013 to November 2015. Electrophysiological sacral reflex detection and SSEP detection were performed using the Keypoint EMG/EP system. The extraction rate, latency, and amplitude of the sacral reflex and SSEP in the MSA group and control group were compared. Results. The sacral reflex latency and amplitude in patients with MSA were statistically different from those of the healthy controls. The latency of sacral reflex increases with the prolongation of the disease course, and the amplitude and initiation rate decrease with the prolongation of the disease course. There was no significant difference in sacral reflex latency and amplitude between MSA patients of different ages and subtypes. There was no significant difference in the latency or amplitude of SSEP between the MSA group and healthy control group. Conclusions. The latency of sacral reflex increases with the prolongation of the disease course, and the amplitude and extraction rate decrease with the prolongation of the disease course. There was no significant difference in the parameters of sacral reflex between young MSA patients and elderly patients. And there was no statistically significant difference between MSA-P subtypes and MSA-C subtypes. This trial is registered with ISRCTNCR2009041.

中文翻译：

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多系统萎缩患者的骶骨反射特征。

目标。观察和分析多系统萎缩（MSA）患者骶反射和阴部神经体感诱发电位（SSEP）参数的年龄、病程、亚型等因素，为MSA的临床诊断提供依据. 材料和方法。2013年5月至2015年11月从温州医科大学第一附属医院共选择51名MSA患者和30名健康对照者。使用Keypoint EMG/EP系统进行电生理骶反射检测和SSEP检测。比较MSA组和对照组骶反射和SSEP的提取率、潜伏期和幅度。结果. MSA患者的骶神经反射潜伏期和幅度与健康对照组相比有统计学差异。骶反射潜伏期随着病程的延长而增加，幅度和起始率随着病程的延长而降低。不同年龄和亚型的MSA患者的骶反射潜伏期和幅度无显着差异。MSA组与健康对照组SSEP的潜伏期或波幅无显着差异。结论. 骶神经反射的潜伏期随着病程的延长而增加，幅度和提取率随着病程的延长而降低。年轻MSA患者和老年患者的骶骨反射参数无显着差异。MSA-P亚型与MSA-C亚型之间差异无统计学意义。该试验已在 ISRCTNCR2009041 注册。