Organisation of Gangliosides into Membrane Nanodomains,FEBS Letters

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Organisation of Gangliosides into Membrane Nanodomains
FEBS Letters ( IF 3.0 ) Pub Date : 2020-07-10 , DOI: 10.1002/1873-3468.13871
Maria J Sarmento ₁ , Joana C Ricardo ₁ , Mariana Amaro ₁ , Radek Šachl ₁

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Gangliosides are glycosphingolipids consisting of a ceramide base and a bulky sugar chain that contains one or more sialic acids. This unique structure endows gangliosides with a strong tendency to self‐aggregate in solution, as well as in cellular membranes, where they can form nanoscopic assemblies called ganglioside nanodomains. As gangliosides are important biological molecules involved in a number of physiological processes, characterization of their lateral organization in membranes is essential. This review aims at providing comprehensive information about the nanoscale organization of gangliosides in various synthetic models. To this end, the impact of the hydrophobic backbone and the headgroup on the segregation of gangliosides into nanodomains are discussed in detail, as well as the way in which the properties of nanodomains are affected by ligand binding. Small size makes the characterization of ganglioside nanodomains challenging, and we thus highlight the biophysical methods that have advanced this research, such as Monte Carlo Förster resonance energy transfer, atomic force microscopy and approaches based on molecular diffusion.

中文翻译：

将神经节苷脂组织成膜纳米域

神经节苷脂是由神经酰胺碱和含有一种或多种唾液酸的大糖链组成的糖鞘脂。这种独特的结构使神经节苷脂在溶液和细胞膜中具有很强的自聚集倾向，在那里它们可以形成称为神经节苷脂纳米域的纳米级组件。由于神经节苷脂是参与许多生理过程的重要生物分子，因此对它们在膜中的横向组织的表征是必不可少的。本综述旨在提供有关各种合成模型中神经节苷脂纳米级组织的综合信息。为此，详细讨论了疏水主链和头基对神经节苷脂分离成纳米域的影响，以及纳米域的特性受配体结合影响的方式。小尺寸使神经节苷脂纳米域的表征具有挑战性，因此我们强调了推动这项研究的生物物理方法，例如蒙特卡罗福斯特共振能量转移、原子力显微镜和基于分子扩散的方法。

更新日期：2020-07-10

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