A comparison of ionization efficiency for gold and silver nanoparticles used as an active media of matrix‐less laser desorption/ionization (LDI) mass spectrometry (MS) methods was made for carboxylic acids including fatty acids. The matrix‐assisted laser desorption/ionization (MALDI)‐type targets containing monoisotopic cationic ¹⁰⁹Ag nanoparticles (¹⁰⁹AgNPs) and Au nanoparticles (AuNPs) were used for rapid MS measurements of 10 carboxylic acids of different chemical properties. Carboxylic acids were directly quantified in experiments with 10 000‐fold concentration change conditions ranging from 1 mg/ml to 100 ng/ml which equates to 1 μg to 100 pg of carboxylic acids per measurement spot.

中文翻译：

---

基于金和银纳米粒子的激光解吸/电离质谱法，用于检测和定量羧酸。

对于含脂肪酸的羧酸，对用作无基质激光解吸/电离（LDI）质谱（MS）方法的活性介质的金和银纳米颗粒的电离效率进行了比较。包含单同位素阳离子¹⁰⁹ Ag纳米颗粒（¹⁰⁹ AgNPs）和Au纳米颗粒（AuNPs）的基质辅助激光解吸/电离（MALDI）型靶标用于快速MS测量10种不同化学性质的羧酸。在实验中，使用1万倍至100 ng / ml的10000倍浓度变化条件直接对羧酸进行定量，每个条件下相当于1μg至100 pg羧酸。