Chemical constituents of the Vietnamese marine sponge Gelliodes sp. and their cytotoxic activities,Chemistry & Biodiversity

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Chemical constituents of the Vietnamese marine sponge Gelliodes sp. and their cytotoxic activities
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2020-08-19 , DOI: 10.1002/cbdv.202000303
Dae-Won Ki ₁ , Takeshi Kodama ₁ , Ahmed H El-Desoky _{1,

2} , Chin Piow Wong ₁ , Hien Minh Nguyen _{1,

3} , Kiep Minh Do ₁ , Quang Minh Thai ₄ , Lien Huong Ton Nu ₅ , Hiroyuki Morita ₁

Affiliation

A new decenoic acid derivative, gelliodesinic acid, and a naturally new alkaloid, together with three known furanoterpenoids and two known indole alkaloids, were isolated from the MeOH extract of the marine sponge Gelliodes sp. collected in Vietnam. The chemical structures of the isolated compounds were determined by analyses of 1D‐ and 2D‐NMR and MS data and by comparisons of the data with those reported in the literature. The cytotoxicity assay against HeLa, MCF‐7, and A549 cancer cell lines revealed that the three known furanoterpenes exhibited cytotoxic activities with IC50 values ranging from 23.6 to 75.5 μM against the three cell lines, and that 1H‐indole‐3‐carboxylic acid showed cytotoxicity with an IC50 value of 89.2 μM against A549 cancer cell lines.

中文翻译：

越南海洋海绵 Gelliodes sp. 的化学成分。及其细胞毒活性

从海海绵 Gelliodes sp. 的 MeOH 提取物中分离出一种新的癸烯酸衍生物、gelliodesinic 酸和一种天然新生物碱，以及三种已知的呋喃萜类化合物和两种已知的吲哚生物碱。采集于越南。分离出的化合物的化学结构是通过对 1D 和 2D NMR 和 MS 数据的分析以及通过将数据与文献中报道的数据进行比较来确定的。对 HeLa、MCF-7 和 A549 癌细胞系的细胞毒性试验表明，三种已知的呋喃萜类化合物对三种细胞系均表现出细胞毒活性，IC50 值为 23.6 至 75.5 μM，并且 1H-吲哚-3-羧酸显示出对 A549 癌细胞系具有细胞毒性，IC50 值为 89.2 μM。

更新日期：2020-08-19

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