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A novel approach to production of Chlorella protothecoides oil-loaded nanoparticles via electrospraying method: Modeling of critical parameters for particle sizing
Biotechnology and Applied Biochemistry ( IF 3.2 ) Pub Date : 2020-06-27 , DOI: 10.1002/bab.1977 Canan Yağmur Karakaş 1 , Didem Özçimen 2
Biotechnology and Applied Biochemistry ( IF 3.2 ) Pub Date : 2020-06-27 , DOI: 10.1002/bab.1977 Canan Yağmur Karakaş 1 , Didem Özçimen 2
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Bioactive compounds in algae have chain rings that protect the tissue from chemical damage and disease symptoms. In addition, algal bioactive agents have the ability to stimulate the immune system, protective and therapeutic effects against many diseases, including various types of cancers, coronary heart disease, premature aging, and arthritis. These bioactive compounds also have antioxidant, anticoagulant, antiviral, and anti-inflammatory properties. It is very important to encapsulate these algal compounds for preserving bioactive properties. Two of the most efficient methods used for encapsulation are electrospraying and microemulsion techniques. Although electrospraying is a novel technique to produce nanoparticles in recent years, microemulsion is more conventional method compared with electrospraying. In this study, Chlorella protothecoides oil was encapsulated by using sodium alginate and chitosan biopolymers, and the effects of production parameters of electrospraying and microemulsion methods on the particle size and loading efficiency were investigated. Statistical modeling of critical parameters for particle sizing in microemulsion method and electrospraying technique, which is a novel approach to obtain microalgal oil-loaded nanoparticles, was also presented. It was seen that electrospraying is suitable for obtaining smaller nanoparticles (123.9–610 nm), homogeneous distribution, and higher oil loading efficiency (60%–77%) compared with microemulsion method (756.9–1128.2 nm and 57%–73%).
中文翻译：
一种通过电喷雾法生产原壳小球藻油载纳米颗粒的新方法：颗粒尺寸关键参数的建模
藻类中的生物活性化合物具有保护组织免受化学损伤和疾病症状的链环。此外，藻类生物活性剂具有刺激免疫系统的能力，对多种疾病具有保护和治疗作用，包括各种类型的癌症、冠心病、早衰和关节炎。这些生物活性化合物还具有抗氧化、抗凝血、抗病毒和抗炎特性。封装这些藻类化合物以保持生物活性是非常重要的。用于封装的两种最有效的方法是电喷雾和微乳液技术。虽然电喷雾是近年来生产纳米粒子的新技术，但与电喷雾相比，微乳液是更传统的方法。在这项研究中，使用海藻酸钠和壳聚糖生物聚合物包封原壳小球藻油，研究了电喷雾和微乳液法生产参数对粒径和负载效率的影响。还介绍了微乳液法和电喷雾技术中粒径的关键参数的统计建模，这是一种获得微藻油负载纳米颗粒的新方法。可以看出，与微乳液法（756.9-1128.2 nm 和 57%-73%）相比，电喷雾适合获得更小的纳米颗粒（123.9-610 nm）、均匀分布和更高的载油效率（60%-77%）。
更新日期：2020-06-27
中文翻译：
一种通过电喷雾法生产原壳小球藻油载纳米颗粒的新方法：颗粒尺寸关键参数的建模
藻类中的生物活性化合物具有保护组织免受化学损伤和疾病症状的链环。此外，藻类生物活性剂具有刺激免疫系统的能力，对多种疾病具有保护和治疗作用，包括各种类型的癌症、冠心病、早衰和关节炎。这些生物活性化合物还具有抗氧化、抗凝血、抗病毒和抗炎特性。封装这些藻类化合物以保持生物活性是非常重要的。用于封装的两种最有效的方法是电喷雾和微乳液技术。虽然电喷雾是近年来生产纳米粒子的新技术，但与电喷雾相比，微乳液是更传统的方法。在这项研究中，使用海藻酸钠和壳聚糖生物聚合物包封原壳小球藻油，研究了电喷雾和微乳液法生产参数对粒径和负载效率的影响。还介绍了微乳液法和电喷雾技术中粒径的关键参数的统计建模，这是一种获得微藻油负载纳米颗粒的新方法。可以看出，与微乳液法（756.9-1128.2 nm 和 57%-73%）相比，电喷雾适合获得更小的纳米颗粒（123.9-610 nm）、均匀分布和更高的载油效率（60%-77%）。
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