To explore the role of POTEE in the malignant development of pancreatic cancer and the possible mechanism. POTEE levels in pancreatic cancer samples were detected. The relationship between POTEE level and clinical data of pancreatic cancer patients was analyzed. After knockdown of POTEE or treatment of the GSK‐3β inhibitor, proliferative change in pancreatic cancer cells was assessed. Protein levels of vital genes in the PI3K/Akt/GSK‐3β/β‐catenin signaling influenced by POTEE were examined. POTEE was upregulated in pancreatic cancer samples. High level of POTEE indicated advanced tumor staging, large tumor size, and poor prognosis in pancreatic cancer patients. Knockdown of POTEE or treatment of Tideglusib remarkably attenuated proliferative ability in pancreatic cancer cells. Vital genes in the PI3K/Akt/GSK‐3β/β‐catenin signaling were downregulated by knockdown of POTEE. POTEE stimulates the proliferative ability in pancreatic cancer by activating the PI3K/Akt/GSK‐3β/β‐catenin signaling. High level of POTEE indicates advanced tumor staging, large tumor size and poor prognosis in pancreatic cancer patients.

中文翻译：

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POTEE 通过激活 PI3K/Akt/GSK-3β/β-catenin 信号传导来刺激胰腺癌的增殖。

探讨POTEE在胰腺癌恶性发展中的作用及可能机制。检测胰腺癌样本中的 POTEE 水平。分析POTEE水平与胰腺癌患者临床资料的关系。在敲除 POTEE 或治疗 GSK-3β 抑制剂后，评估了胰腺癌细胞的增殖变化。检查受 POTEE 影响的 PI3K/Akt/GSK-3β/β-catenin 信号传导中重要基因的蛋白质水平。POTEE 在胰腺癌样本中上调。高水平的 POTEE 表明胰腺癌患者的肿瘤分期先进、肿瘤体积大、预后差。POTEE 的敲除或 Tideglusib 的治疗显着减弱了胰腺癌细胞的增殖能力。PI3K/Akt/GSK-3β/β-catenin 信号中的重要基因被 POTEE 的敲低下调。POTEE 通过激活 PI3K/Akt/GSK-3β/β-catenin 信号来刺激胰腺癌的增殖能力。高水平的 POTEE 表明胰腺癌患者肿瘤分期先进、肿瘤体积大、预后差。