An Au nanoparticle-(Au NP)-doped molecularly imprinted photonic crystal (Au-MIPC) is successfully prepared for naked-eye analysis. The resultant crystal displays a periodically ordered inverse opal structure. The proposed photonic crystal (PC) overtly reveals a 69 nm red shift accompanied by a naked-eye distinguishable structural color change from blue to green when detecting bisphenol A from 1 ng ml⁻¹ to 1 mg ml⁻¹. By comparing the detection results of the MIPC without Au NPs with those of non-molecularly imprinted PCs (NIPCs) with and without Au NPs, we note that the introduction of Au NPs can effectively amplify the response signal but it does not interfere with the response signals of NIPCs. The naked-eye distinguishable color change and amplification effect are also observed in monocrotophos- and ractopamine-imprinted Au-MIPCs. All of these Au-MIPCs possess high selectivity for target molecules. Thus, Au-MIPCs can potentially be applied to the equipment-free detection of various molecules in-field to facilitate significant naked-eye detection as pH paper. We expect to form new functional photonic materials or sensors for molecular analysis.

成功地制备了金纳米粒子（Au NP）掺杂的分子印迹光子晶体（Au-MIPC），用于肉眼分析。所得晶体显示出周期性有序的反蛋白石结构。当检测从1 ng ml ^-1到1 mg ml ^-1的双酚A时，建议的光子晶体（PC）明显显示出69 nm的红移，并带有肉眼可分辨的从蓝色到绿色的结构颜色变化。。通过比较不带金NP的MIPC和带或不带金NP的非分子印迹PC（NIPC）的检测结果，我们注意到引入金NP可以有效放大响应信号，但不会干扰响应NIPC的信号。在久效磷和莱克多巴胺印迹的Au-MIPC中也观察到了肉眼可分辨的颜色变化和放大效果。所有这些Au-MIPC具有对目标分子的高选择性。因此，Au-MIPCs可以潜在地应用于无设备现场检测各种分子，从而可以像pH纸一样方便地进行肉眼检测。我们期望形成用于分子分析的新型功能性光子材料或传感器。