Despite growing applications of molybdenum(IV) sulfide (MoS₂) nano- and microparticles in their capacity as lubricants, data available on their safety are scarce. In this study the effect of MoS₂ nano- and microparticles after single intratracheal instillation in rats has been analyzed. MoS₂ suspensions were administered at the dose of 1.5 or 5 mg MoS₂/kg body weight. The analysis after 24 h and 7 days included: blood biochemical parameters, hematological parameters, bronchoalveolar lavage fluid (BALF) parameters with selected cytokines, a comet assay and histopathological examination.

In the BALF cells isolated from animals exposed to both forms, numerous macrophages loaded with particles were observed. The hematological and biochemical parameters analyzed 24 h or 7 days after the exposure to both forms did not show any biologically meaningful changes. Comet assay results showed no genotoxic effect. The histopathological analysis of the lungs revealed inflammatory changes in the respiratory system of the treated animals, slightly stronger for the microsized form. The deposits of particles observed in the lung tissue up to 7 days after the instillation indicate their easy penetration through the epithelium and prolonged clearance. Concluding, no meaningful acute systemic effects were observed, however some pathological changes were noted in the lung tissue.

尽管硫化钼（MoS ₂）纳米和微粒作为润滑剂的应用越来越多，但有关其安全性的可用数据却很少。在这项研究中，已经分析了单次气管内滴注大鼠后MoS ₂纳米和微粒的作用。以1.5或5mg MoS ₂ / kg体重的剂量施用MoS ₂悬浮液。24小时和7天后的分析包括：血液生化参数，血液学参数，支气管肺泡灌洗液（BALF）参数以及所选的细胞因子，彗星试验和组织病理学检查。

在从暴露于两种形式的动物的BALF细胞中，观察到大量的巨噬细胞装载了颗粒。暴露于两种形式后24小时或7天分析的血液和生化参数均未显示任何生物学意义的变化。彗星试验结果显示没有遗传毒性作用。肺的组织病理学分析显示，经治疗的动物的呼吸系统发生炎性变化，对于微尺寸形式的动物则稍强。滴注后长达7天在肺组织中观察到的颗粒沉积物表明它们易于穿过上皮并延长了清除时间。最后，未观察到有意义的急性全身作用，但是在肺组织中发现了一些病理变化。