The objective of this retrospective cohort study was to determine the impact of a recent trauma on thyroid axis and adrenal activity in dogs and to assess the usefulness of urinary cortisol-to-creatinine ratio (UCCR), basal serum thyroid-stimulating hormone (TSH), total thyroxine (tT4), and free thyroxine (fT4) concentrations in predicting outcome in dogs traumatized by a road traffic accident (RTA).

An RTA exposed group of 210 dogs was evaluated within 24 hours of the trauma. Their data were compared with data from a matched group of dogs with other diagnoses.

UCCR was positively correlated with the trauma severity and was higher in the exposed group than in the nonexposed group (median 101.500 vs. 21.02; p < 0.0001). tT4 values were statistically similar between the two groups, but were correlated with a trauma score, while TSH (median = 0.050 vs. 0.080 ng/mL; p < 0.0001) and fT4 (median = 15.850 vs. 17.950 pmol/L; p = 0.0037) were significantly lower for the exposed group.

Nonsurvivors in comparison to survivors presented and higher median UCCR (181.800 vs. 93.850 respectively; p = 0.020), and a lower serum fT4 (12.700 vs. 16.500 pmol/L, respectively; p = 0.0046). A similar pattern had been observed for tT4. TSH levels were not predictive of survival.

This study provides insights into the endocrine characteristics of dogs suffering from acute trauma. UCCR was higher while fT4 and TSH were both lower in RTA-injured dogs than in dogs affected by other conditions. Furthermore low fT4 and tT4, and a high UCCR could be useful prognostic factors in dogs affected by RTA trauma.

这项回顾性队列研究的目的是确定近期创伤对犬甲状腺轴和肾上腺活动的影响，并评估尿皮质醇与肌酐之比（UCCR），基础血清促甲状腺激素（TSH）的有效性，总甲状腺素（tT4）和游离甲状腺素（fT4）浓度可预测因道路交通事故（RTA）受伤的狗的结局。

在创伤的24小时内评估了暴露于RTA的210只狗。将他们的数据与具有其他诊断结果的配对狗的数据进行比较。

UCCR与创伤严重程度呈正相关，并且暴露组的UCCR高于未暴露组（中位数101.500对21.02；p  <0.0001）。两组之间的tT4值在统计上相似，但与创伤评分相关，而TSH（中位数= 0.050对0.080 ng / mL；p  <0.0001）和fT4（中位数= 15.850对17.950 pmol / L；p  = 0.0037）显着低于暴露组。

与幸存者相比，非幸存者的UCCR中位数较高（分别为181.800和93.850；p  = 0.020）和血清fT4较低（分别为12.700和16.500 pmol / L；p  = 0.0046）。对于tT4，已经观察到类似的模式。TSH水平不能预测生存。

这项研究为患有急性创伤的狗的内分泌特征提供了见识。与受其他疾病影响的犬相比，RTA损伤犬的UCCR较高，而fT4和TSH均较低。此外，较低的fT4和tT4以及较高的UCCR可能是受RTA创伤的犬有用的预后因素。