Objectives of this study were to evaluate the alleviating effects of a commercial beta-1,3-glucan product (Aleta, containing 50% beta-1,3-glucan, Kemin Industries) on metabolic stress in transition Holstein cows as reflected by circulating metabolites and enzymes. Fifty-four multiparous Holstein cows were randomly allocated to three groups with 18 cows each. Cows in each group received a commercial basal diet or the basal diet supplemented with Aleta calculated to supply 5 or 10 g of Aleta per cow per day. Blood samples were collected at day −21, 1, and 21 relative to calving for determination of serum triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDLC), very low density lipoprotein (VLDL), glucose, insulin, β-hydroxybutyric acid (BHBA), aspartate aminotransferase (AST), alanine aminotransferase (ALT), glutamyl transpeptidase (GGT), and non-esterified fatty acid (NEFA). Supplementation with Aleta markedly elevated serum concentrations of TG, TC, HDLC, LDL-C and VLDL, implying its positive effect on lipid metabolism in transition dairy cows. Aleta treatment significantly decreased the serum concentrations of NEFA and BHBA, but markedly elevated the serum concentrations of glucose and insulin. Also, Aleta treatment significantly elevated the dry matter intake and milk production in postpartum cows, indicating the alleviating effect of Aleta on negative energy balance in transition cows. Moreover, Aleta treatment significantly reduced the serum activities of AST, ALT and GGT, indicating its hepatoprotective effect on transition cows. These results suggest that Aleta supplementation may help to improve fat metabolism disorder initiated by negative energy balance in transition dairy cows.

这项研究的目的是评估商业化的β-1,3-葡聚糖产品（Aleta，含50％β-1,3-葡聚糖，Kemin Industries）对过渡型荷斯坦奶牛代谢应激的缓解作用，这是通过循环代谢物反映的。和酶。将54头多头荷斯坦奶牛随机分为三组，每组18头。每组奶牛接受商业基础饮食或补充有Aleta的基础饮食，计算出每头母牛每天供应5或10 g Aleta。相对于产犊在第-21、1、21天采集血液样本，以测定血清甘油三酸酯（TG），总胆固醇（TC），低密度脂蛋白胆固醇（LDL-C），高密度脂蛋白胆固醇（HDL C），极低密度脂蛋白（VLDL），葡萄糖，胰岛素，β-羟基丁酸（BHBA），天冬氨酸转氨酶（AST），丙氨酸转氨酶（ALT），谷氨酰转肽酶（GGT）和非酯化脂肪酸（NEFA）。补充Aleta可以显着提高血清TG，TC，HDL C，LDL-C和VLDL的浓度，这表明其对过渡奶牛的脂质代谢具有积极作用。Aleta治疗血清显著降低浓度NEFA和BHBA的，但显着升高的血清浓度葡萄糖和胰岛素。此外，Aleta处理显着提高了产后母牛的干物质摄入量和产奶量，表明Aleta对过渡母牛负能量平衡的缓解作用。此外，Aleta处理可显着降低AST，ALT和GGT的血清活性，表明其对转基因奶牛具有保肝作用。这些结果表明，Aleta补充剂可能有助于改善由过渡型奶牛的负能量平衡引发的脂肪代谢紊乱。