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The Preoperative Evaluation of Drug-Resistant Epilepsy.
Pediatric Neurology ( IF 3.2 ) Pub Date : 2020-06-27 , DOI: 10.1016/j.pediatrneurol.2020.05.010
Dave F Clarke 1 , Ekta G Shah 1 , Freedom F Perkins 1
Affiliation  

Antiepileptic drugs afford good seizure control for approximately 70% of individuals with epilepsy. Epilepsy surgery is extremely helpful for appropriate individuals with drug resistance. Since antiquity, trephination was a crude and invasive technique to manage epilepsy. The late 1800s saw the advent of a more evidence-based approach with attempts to define seizure foci and determine areas of function. Seizure localization initially required direct brain stimulation during surgery before resection. Fortunately, improved knowledge of seizure semiology and advancements in preoperative investigations have enabled epilepsy specialists to better analyze the benefit of seizure reduction versus risk of functional harm. This preoperative phase and the investigative techniques used to analyze surgical candidacy will be discussed in this article.



中文翻译:

耐药性癫痫的术前评估。

抗癫痫药物对大约 70% 的癫痫患者提供了良好的癫痫发作控制。癫痫手术对于具有耐药性的适当个体非常有帮助。自古以来,环钻术是一种治疗癫痫的粗略侵入性技术。1800 年代后期出现了一种更基于证据的方法,试图定义癫痫发作灶并确定功能区域。癫痫发作定位最初需要在手术过程中进行直接脑刺激,然后再切除。幸运的是,癫痫符号学知识的提高和术前检查的进步使癫痫专家能够更好地分析减少癫痫发作的益处与功能损害的风险。本文将讨论术前阶段和用于分析手术候选资格的调查技术。

更新日期:2020-06-27
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