To evaluate cerebrospinal fluid (CSF) and peripheral blood (PB) Treg, TH17 cells, TH1, TH2 and related cytokines in the acute phase of aSAH we assessed TH17, TH1, TH2, T regulatory cells and neutrophils in 39 aneurysmal subarachnoid hemorrhage (aSAH) patients and 56 controls. PB TH17 cells and TH17/Treg ratio were higher in CSF and PB of aSAH patients. Serum and CSF IL-17A levels were increased in aSAH. Serum IL-17A levels were associated with vasospasm and ICU mortality. Study results support the role of TH17/IL17 axis in aSAH pathogenesis, turning it into a potential clinical biomarker and a novel target for research.

中文翻译：

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严重动脉瘤性蛛网膜下腔出血后TH17/Treg失衡和IL-17A增加

为了评估 aSAH 急性期的脑脊液 (CSF) 和外周血 (PB) Treg、TH17 细胞、TH1、TH2 和相关细胞因子，我们评估了 39 例动脉瘤性蛛网膜下腔出血 (aSAH) 中的 TH17、TH1、TH2、T 调节细胞和中性粒细胞) 患者和 56 名对照。PB TH17 细胞和 TH17/Treg 比值在 aSAH 患者的 CSF 和 PB 中较高。血清和脑脊液 IL-17A 水平在 aSAH 中增加。血清 IL-17A 水平与血管痉挛和 ICU 死亡率相关。研究结果支持 TH17/IL17 轴在 aSAH 发病机制中的作用，使其成为潜在的临床生物标志物和新的研究靶点。