In 2010, cytidine 5′-triphosphate synthase (CTPS) was reported to form the filamentous or serpentine structure in Drosophila, which we termed the cytoophidium. In the last decade, CTPS filaments/cytoophidia have been found in bacteria, budding yeast, human cells, mice, fission yeast, plants, and archaea, indicating that this mechanism is highly conserved in evolution. In addition to CTPS, other metabolic enzymes have been identified to have the characteristics of forming cytoophidia or similar advanced structures, demonstrating that this is a basic strategy of cells. Nevertheless, our understanding of the physiological function of the cytoophidium remains incomplete and elusive. Here, we took the larva of Drosophila melanogaster as a model to systematically describe the localization and distribution of cytoophidia in different tissues during larval development. We found that the distribution pattern of CTPS cytoophidia is dynamic and heterogenic in larval tissues. Our study provides a road map for further understanding of the function and regulatory mechanism of cytoophidia.

在2010年，据报道胞嘧啶5'-三磷酸合酶（CTPS）在果蝇中形成丝状或蛇形结构，我们称其为细胞质。在过去的十年中，在细菌，出芽的酵母，人类细胞，小鼠，裂变酵母，植物和古细菌中发现了CTPS丝/细胞丝，这表明该机理在进化中高度保守。除CTPS以外，其他代谢酶也已被鉴定具有形成细胞吞噬作用或类似高级结构的特征，这证明这是细胞的基本策略。然而，我们对细胞膜的生理功能的理解仍然不完整和难以捉摸。在这里，我们采取了果蝇果蝇的幼虫作为模型来系统地描述幼虫发育过程中不同组织中细胞色素的定位和分布。我们发现，在幼虫组织中，CTPS胞吞的分布模式是动态且异质的。我们的研究提供了进一步理解细胞吞噬功能和调控机制的路线图。