Candida albicans is a major cause of fungal nosocomial infections. Host defense against disseminated infections caused by this yeast strongly relies on myeloid cells of the innate immune system. Recently, several breakthroughs have been made that significantly improved our understanding of the role of macrophages during candidiasis and how C. albicans and macrophages interact. Resident tissue macrophages and macrophages derived from monocytes that infiltrate infected tissues are essential for the initiation of the antifungal immune response, as well as elimination of C. albicans from the bloodstream and infected organs. These cells engulf and try to eliminate the invading fungi through specialized mechanisms. Concurrently, C. albicans tries to survive the stresses imposed by the macrophage, acquires nutrients, and can break free from their captive environment. This review focuses on the most recent insights into the strategies of macrophages to eliminate C. albicans and the fungal counterstrategies to overcome these threats.

白色念珠菌是真菌医院感染的主要原因。抵抗由该酵母引起的传播感染的宿主防御强烈依赖于先天免疫系统的髓样细胞。最近，已经取得了一些突破，这些突破显着改善了我们对念珠菌病中巨噬细胞的作用以及白色念珠菌和巨噬细胞如何相互作用的理解。驻留组织巨噬细胞和来源于单核细胞的巨噬细胞会渗透到感染的组织中，对于启动抗真菌免疫反应以及从血流和感染的器官中消除白色念珠菌至关重要。这些细胞吞噬并试图通过专门的机制消除入侵的真菌。同时，白色念珠菌试图抵抗巨噬细胞施加的压力，获取营养，并摆脱圈养环境。这篇综述着重于对巨噬细胞消除白色念珠菌的策略以及克服这些威胁的真菌对策的最新见解。