Although soluble mediators of our innate immune system have a substantial impact on invading microbes, their role against fungal pathogens has been underexplored. Constituting the humoral immunity, soluble mediators comprise the complement system, collectins, acute-phase proteins, antibodies and antimicrobial peptides. These components can prevent fungal infection either by directly interacting with invading microbes, leading to their aggregation (microbistatic), destruction (microbicidal) or linking them to cellular immunity. The composition of soluble-mediator varies with human body-fluids, resulting in different antifungal mechanisms. Moreover, cellular immune system deploys both oxidative and non-oxidative mechanisms to destroy extracellular or internalized fungal pathogens; however, cellular immune activation is mainly influenced as well as regulated by soluble mediators. This review outlines the antifungal mechanism employed, directly or indirectly, by soluble mediators, and in response, the evading strategies of the fungal pathogens.

尽管我们先天免疫系统的可溶性介体对入侵微生物具有实质性影响，但其对真菌病原体的作用尚未得到充分研究。构成体液免疫的可溶性介质包括补体系统，collectin，急性期蛋白，抗体和抗菌肽。这些成分可通过与入侵的微生物直接相互作用，导致其聚集（抑菌），破坏（杀微生物）或将其与细胞免疫联系起来，从而防止真菌感染。可溶性介体的组成随人体流体而变化，从而导致不同的抗真菌机制。此外，细胞免疫系统利用氧化和非氧化机制破坏细胞外或内在的真菌病原体。然而，细胞免疫激活主要受可溶性介质的影响和调节。这篇综述概述了可溶性介质直接或间接采用的抗真菌机制，以及对真菌病原体规避策略。