Background and objective

Levodopa/carbidopa intestinal gel infusion is a treatment option for patients of advanced stage of Parkinson's disease. This treatment requires the time-consuming and error-prone conversion of orally taken antiparkinson drugs into an equivalent replacing dose of levodopa/carbidopa, which is delivered via pump. In order to facilitate and speed up this conversion process, we developed a specific user-friendly application that would be available online or as a standalone mobile application. Such an application has now been written and designed in collaboration with a computer scientist and physician, who is also intended to be the final user.

Methods

The levodopa equivalent dose calculations are based on previous studies and data reported in the literature. Two related on-line conversion applications were analyzed and evaluated. The primary objectives of the application were determined, and basic functionalities were outlined. The application was implemented using modern development tools and frameworks.

Results

The application has proven to be effective and easy to use in our clinical setting. It can serve as a control for manual calculations made by medical staff. It can also be applied as a useful tool in levodopa/carbidopa intestinal gel infusion courses for the advanced treatment of Parkinson's disease.

Conclusion

The presented application could replace the tedious and error-prone levodopa equivalent dose conversion of antiparkinson drugs efficiently. In comparison to related on-line conversion applications, this specific application provides more functionality, reduces the risk of user errors, and can be run on a variety of devices. The conversion value provided by the application is only an estimate. The effect of the drugs is specific for each individual patient, which could not be considered in the calculations. Therefore, the responsibility of using the results of the application rests with the clinical judgment of the user. Nevertheless, the application can give us a good starting point for the initial pump setting, which would be adjusted further during the titration period, according to the patient's response.

中文翻译：

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EQUIDopa：左旋多巴等效剂量计算器的自适应Web应用程序。

背景和目标

左旋多巴/卡比多巴肠凝胶输注是帕金森氏病晚期患者的治疗选择。这种治疗需要将口服抗帕金森药物转换为等效替代剂量的左旋多巴/卡比多巴，既费时又容易出错，该剂量可通过泵输送。为了促进和加快此转换过程，我们开发了一个特定的用户友好型应用程序，该应用程序可以在线获得，也可以作为独立的移动应用程序使用。现在已经与计算机科学家和医生合作编写和设计了这样的应用程序，他们也打算成为最终用户。

方法

左旋多巴等效剂量的计算是基于以前的研究和文献中报道的数据。分析和评估了两个相关的在线转换应用程序。确定了应用程序的主要目标，并概述了基本功能。该应用程序是使用现代开发工具和框架实现的。

结果

该应用程序已被证明在我们的临床环境中有效且易于使用。它可以用作医务人员进行手动计算的控件。它也可以作为左旋多巴/卡比多巴肠道凝胶输注疗程中的有用工具，用于帕金森氏病的晚期治疗。

结论

提出的申请可以有效地代替单调的，易于出错的左帕金森药的左旋多巴等效剂量转换。与相关的在线转换应用程序相比，此特定应用程序提供更多的功能，降低用户错误的风险，并且可以在各种设备上运行。应用程序提供的转换值仅是估计值。药物的作用对每位患者都是特定的，在计算中无法考虑。因此，使用应用程序结果的责任在于用户的临床判断。但是，该应用程序可以为我们提供初始泵设置的良好起点，可以根据患者的反应在滴定期间进一步进行调整。