In order to improve the anticancer therapeutic efficacy and postoperative recovery efficacy, the novel anticancer therapeutic system should have the ability to promote angiogenesis after anticancer therapy besides the excellent anticancer therapeutic efficacy. We present herein a magnetic targeting multifunctional anticancer therapeutic system based on cobalt nanowires (CoNWs) for anticancer therapy and angiogenesis. Magnetic characterization shows that the CoNWs can be concentrated in desired locations under the external magnetic field, which is favorable for anticancer target therapy. Besides, drug loading/release characterization reveals that the CoNWs interact with doxorubicin (DOX) by electrostatic interaction, and accordingly form a composite which can release DOX with temperature increase under near-infrared light (NIR) treatment. And anticancer test reveals that the nanowires loaded with the DOX (CoNWs-DOX) can produce an effective chemo-photothermal synergistic therapeutic effect against murine breast cancer cell lines (4T1) and human osteosarcoma cell lines (MG63) under NIR treatment. Furthermore, angiogenesis assessment reveals that the released cobalt ion from the nanowires can significantly enhance the angiogenesis efficacy after cancer treatment. These results suggest that the constructed anticancer therapeutic system provides a promising multifunctional platform for cancer treatment and postoperative recovery.

为了提高抗癌治疗效果和术后恢复效果，除了优异的抗癌治疗效果之外，新型抗癌治疗系统还应具有促进抗癌治疗后血管新生的能力。我们在本文中提出了基于钴纳米线（CoNWs）的磁性靶向多功能抗癌治疗系统，用于抗癌治疗和血管生成。磁性表征表明，CoNWs可以集中在外部磁场下的所需位置，这对于抗癌目标治疗是有利的。此外，载药/释放特征表明，CoNWs通过静电相互作用与阿霉素（DOX）相互作用，因此形成了可以在近红外（NIR）处理下随温度升高释放DOX的复合物。抗癌试验表明，载有DOX（CoNWs-DOX）的纳米线可在NIR治疗下对鼠类乳腺癌细胞系（4T1）和人骨肉瘤细胞系（MG63）产生有效的化学光热协同治疗作用。此外，血管生成评估显示从纳米线释放的钴离子可以显着增强癌症治疗后的血管生成功效。这些结果表明，所构建的抗癌治疗系统为癌症治疗和术后康复提供了有希望的多功能平台。此外，血管生成评估显示从纳米线释放的钴离子可以显着增强癌症治疗后的血管生成功效。这些结果表明，所构建的抗癌治疗系统为癌症治疗和术后康复提供了有希望的多功能平台。此外，血管生成评估显示从纳米线释放的钴离子可以显着增强癌症治疗后的血管生成功效。这些结果表明，所构建的抗癌治疗系统为癌症治疗和术后康复提供了有希望的多功能平台。