Wet granulation is a process used in the pharmaceutical industry to improve raw materials flow and compressibility. Adequate granulation process to manufacture furazolidone (FZD) is not in place, which may compromise the quality and performance of the final product. In this study, statistical planning and rheological analysis using Mixer Torque Rheometer (MTR) were employed to evaluate the influence of microcrystalline cellulose (MCC 101), sodium lauryl sulfate (SLS), and different binders on FZD wet granulation. The results revealed a statistically significant influence of MCC 101 and SLS on torque value, whereas MCC 101 increases it by 0.240 N.m, SLS resulted in 0.055 N.m decrease. Moreover, sodium alginate showed better performance as a binder in the FZD granulation than PVP K30. It has also been evidenced how the MTR plays an important role during the wet granulation process, leading to accurate granulation endpoint determination and superior formulation. In conclusion, MTR is an optimal tool to be explored in pharmaceutical formulation, since our results allowed the development of FZD formulations using small amounts of raw material, through rational and non-empirical methods, providing granulates with appropriate characteristics.

湿法制粒是制药工业中用于改善原料流动性和可压缩性的过程。没有足够的制粒工艺来制造呋喃唑酮（FZD），这可能会损害最终产品的质量和性能。在这项研究中，统计计划和流变分析使用混合扭矩流变仪（MTR）被用来评估微晶纤维素（MCC 101），月桂基硫酸钠（SLS）和不同的粘合剂对FZD湿法制粒的影响。结果表明，MCC 101和SLS对扭矩值具有统计学意义的影响，而MCC 101使扭矩值增加0.240 Nm，SLS使扭矩值降低0.055 Nm。此外，海藻酸钠在FZD造粒中作为粘合剂的性能优于PVP K30。还已经证明，MTR在湿法制粒过程中如何发挥重要作用，从而导致精确的制粒终点测定和优异的配方。总之，MTR是在药物制剂中探索的最佳工具，因为我们的结果允许通过合理和非经验方法使用少量原料开发FZD制剂，从而为颗粒提供适当的特性。