Purpose

Recent studies have shown that cytokines secreted from adipose tissues play a role in the pathogenesis of type 2 diabetes mellitus (T2DM). CTRP5 (C1q-TNF-related protein 5) is a novel adipokine that has been shown to be associated with glucose and lipid metabolism. Varying levels of CTRP5 have been reported in individuals with diabetes, obesity and coronary artery disease. The aim of this study was to examine serum levels of CTRP5 and to show the relationship with cardiometabolic parameters in T2DM patients.

Method

The study included 40 T2DM patients and 40 age- and sex-matched healthy control subjects. All the study participants were evaluated with respect to BMI, waist circumference, lipid profile, insulin resistance (HOMA-IR), serum CTRP5 levels, carotid intima-media thickness, and hs-CRP.

Results

No statistically significant differences were found between the control group and the diabetic group in terms of age, sex, or BMI. Serum CTRP5 levels (T2DM = 94.55 ± 28.70 ng/ml, control = 76.02 ± 27.22 ng/ml, P = 0.004*) were significantly higher in the group of newly diagnosed diabetic patients. A positive correlation was found between CTRP5 and the cardiometabolic parameters of carotid intima-media thickness (CIMT), hs-CRP, HOMA-IR and BMI. Regression analysis results showed that CTRP5 levels were independently correlated with insulin resistance estimated by HOMA-IR.

Conclusion

Serum CTRP5 levels were correlated with cardiometabolic parameters and could therefore be a promising indicator of metabolic status and a possible biomarker of insulin resistance. However, the contradictory results reported in different studies indicate the need for further research to assess the significance of CTRP5 for diagnosis and monitoring of treatment efficacy.

中文翻译：

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初诊2型糖尿病患者血清C1q-肿瘤坏死因子相关蛋白5水平与代谢参数及颈动脉内中膜厚度的相关性

目的

最近的研究表明，脂肪组织分泌的细胞因子在 2 型糖尿病 (T2DM) 的发病机制中发挥作用。CTRP5（C1q-TNF 相关蛋白 5）是一种新型脂肪因子，已被证明与葡萄糖和脂质代谢有关。据报道，患有糖尿病、肥胖症和冠状动脉疾病的个体的 CTRP5 水平不同。本研究的目的是检查 CTRP5 的血清水平并显示其与 T2DM 患者心脏代谢参数的关系。

方法

该研究包括 40 名 T2DM 患者和 40 名年龄和性别匹配的健康对照受试者。所有研究参与者都接受了 BMI、腰围、血脂、胰岛素抵抗 (HOMA-IR)、血清 CTRP5 水平、颈动脉内中膜厚度和 hs-CRP 的评估。

结果

对照组和糖尿病组在年龄、性别或 BMI 方面没有发现统计学上的显着差异。 新诊断的糖尿病患者组的血清 CTRP5 水平（T2DM = 94.55 ± 28.70 ng/ml，对照 = 76.02 ± 27.22 ng/ml，P = 0.004*）显着更高。CTRP5与颈动脉内中膜厚度（CIMT）、hs-CRP、HOMA-IR和BMI的心脏代谢参数呈正相关。回归分析结果表明，CTRP5 水平与 HOMA-IR 估计的胰岛素抵抗独立相关。

结论

血清 CTRP5 水平与心脏代谢参数相关，因此可能是代谢状态的一个有希望的指标和胰岛素抵抗的可能生物标志物。然而，不同研究报告的相互矛盾的结果表明需要进一步研究来评估 CTRP5 对诊断和监测治疗效果的重要性。