Aflatoxicosis is a serious health condition resulted from aflatoxin (AF)-producing fungi. Major health threats resulted from AFs and reflect on the livestock industry with great economic losses. There are limited scientific evidences concerning the AFs in ruminant, therefore it is important to evaluate AFs health hazards in cattle. Here, we investigate biochemical, oxidative stress, and postmortem changes associated with unexpected acute bovine aflatoxicosis. Seventy-two cattle were suffered from aflatoxisocis. Depression and inappetence were predominant clinical findings of the diseased animals. Analysis of feedstuffs revealed presence of aflatoxin B1 (AFB1). The AF-intoxicated animals showed a significant increase in alanine amino transferase (ALT), aspartate amino transferase (AST), alkaline phosphatase (ALP), serum creatinine (SCr), catalase (CAT), and malondialdehyde (MDA) levels. Moreover, a significant decrease in total protein (TP), magnesium (Mg), and reduced glutathione (GSH) were also seen. Hepatomegaly, enlarged gallbladder as well as congestion of the intestine and kidney were observed. This study elucidates the critical and constructive measurements needed for the prevention of the AFs hazardous effects to livestock for the future control of AF outbreaks. Conducting series of diagnostic assays reflect the marked health condition alterations in the biochemical and antioxidant status of the AF-intoxicated cattle.

黄曲霉毒素中毒是一种由产生黄曲霉毒素 (AF) 的真菌引起的严重健康状况。AFs 造成的主要健康威胁，反映了畜牧业的巨大经济损失。关于反刍动物AFs的科学证据有限，因此评估AFs对牛的健康危害很重要。在这里，我们研究了与意外的急性牛黄曲霉中毒相关的生化、氧化应激和死后变化。72 头牛患有黄曲霉病。抑郁和食欲不振是患病动物的主要临床表现。饲料分析表明存在黄曲霉毒素 B1 (AFB1)。AF 中毒动物的丙氨酸氨基转移酶 (ALT)、天冬氨酸氨基转移酶 (AST)、碱性磷酸酶 (ALP)、血清肌酐 (SCr)、过氧化氢酶 (CAT) 和丙二醛 (MDA) 水平。此外，还观察到总蛋白 (TP)、镁 (Mg) 和还原型谷胱甘肽 (GSH) 的显着减少。观察到肝肿大、胆囊增大以及肠和肾充血。这项研究阐明了预防 AFs 对牲畜的危险影响所需的关键和建设性的测量，以便未来控制 AF 爆发。进行一系列诊断分析反映了 AF 中毒牛的生化和抗氧化状态的显着健康状况变化。这项研究阐明了预防 AFs 对牲畜的危险影响所需的关键和建设性的测量，以便未来控制 AF 爆发。进行一系列诊断分析反映了 AF 中毒牛的生化和抗氧化状态的显着健康状况变化。这项研究阐明了预防 AFs 对牲畜的危险影响所需的关键和建设性的测量，以便未来控制 AF 爆发。进行一系列诊断分析反映了 AF 中毒牛的生化和抗氧化状态的显着健康状况变化。