Abstract

The current work reports the synthesis of microcrystalline cellulose and polyvinyl alcohol co-polymerized crosslinked hydrogels both via physical and chemical crosslinking. While freeze–thawing ensured the physical crosslinking, the crosslinker, ethylene glycol diglycidyl ether ensured the chemical crosslinking. The obtained hydrogels were characterized by Fourier transform infrared spectroscopy, swelling ratio and rheology. The gels showed good equilibrium swelling ratio in deionized (DI) water and phosphate buffer saline (PBS) buffer. The morphological observation revealed porous and glossy nature of hydrogels. The synthesized hydrogels were used as a carrier for 5-Fluorouracil. The in vitro release of drug was performed in PBS buffer (pH = 7.4), leading to a cumulative release of 30–60% from all the chemically crosslinked gels. The kinetic release mechanism suggested the release of drug was mostly due to the controlled Fickian diffusion and swelling of gels.

Graphic abstract

中文翻译：

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物理和化学交联的微晶纤维素-聚乙烯醇水凝胶：冻融介导的5-氟尿嘧啶的合成，表征和体外递送

摘要

当前的工作报道了通过物理和化学交联来合成微晶纤维素和聚乙烯醇共聚的交联水凝胶。冻融可确保物理交联，而交联剂乙二醇二缩水甘油醚可确保化学交联。通过傅立叶变换红外光谱，溶胀率和流变学对所得水凝胶进行表征。该凝胶在去离子（DI）水和磷酸盐缓冲盐水（PBS）缓冲液中显示出良好的平衡溶胀率。形态观察揭示了水凝胶的多孔和光泽性质。合成的水凝胶用作5-氟尿嘧啶的载体。在PBS缓冲液（pH = 7.4）中进行药物的体外释放，导致所有化学交联凝胶的累积释放量为30–60％。

图形摘要