Combined antiretroviral therapy has improved quality and life expectancy of people living with human immunodeficiency virus (HIV). However, this therapy increases oxidative stress (OS), which in turn causes alterations in lipid and carbon metabolism, kidney disease, liver cirrhosis, and increased risk of cardiovascular disease. The Klotho gene has been implicated in cardiovascular risk increase. Klotho protein expression at X level decreases the risk of heart disease. HIV-positive people usually present low plasma levels of Klotho; thus, contributing to some extent to an increase in cardiovascular risk for these types of patients, mostly by favoring atherosclerosis. Therefore, our aim is to provide an overview of the effect of OS on Klotho protein and its consequent cardiometabolic alterations in HIV-positive patients on antiretroviral therapy.

中文翻译：

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Klotho-HIV和氧化应激：Klotho在HIV感染下在心血管疾病中的作用-综述。

联合抗逆转录病毒疗法已改善了人类免疫缺陷病毒（HIV）患者的质量和预期寿命。但是，这种疗法会增加氧化应激（OS），进而导致脂质和碳代谢，肾脏疾病，肝硬化和心血管疾病的风险增加。Klotho基因与心血管疾病风险增加有关。X级别的Klotho蛋白表达降低了患心脏病的风险。艾滋病毒抗体阳性的人血浆中Klotho的水平通常较低；因此，主要是通过促进动脉粥样硬化，在某种程度上增加了这类患者的心血管风险。因此，我们的目的是概述OS对Klotho蛋白的影响及其在抗逆转录病毒治疗的HIV阳性患者中的心脏代谢变化。