Merger of C-F and C-N Bond Cleavage in Cross-Electrophile Coupling for the Synthesis of gem-Difluoroalkenes.,Organic Letters

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Merger of C-F and C-N Bond Cleavage in Cross-Electrophile Coupling for the Synthesis of gem-Difluoroalkenes.
Organic Letters ( IF 4.9 ) Pub Date : 2020-06-26 , DOI: 10.1021/acs.orglett.0c01592
Youxiang Jin ₁ , Jiaoyang Wu ₁ , Zhiyang Lin ₁ , Yun Lan ₁ , Chuan Wang _{1,

2}

Affiliation

Herein we successfully applied Katritzky salts as the alkyl electrophile in the reductive allylic defluorinative cross-coupling reaction with α-trifluoromethyl alkenes. The merger of C–F and C–N bond cleavage via the synergistic effect of nickel and zinc allows the efficient synthesis of diverse gem-difluoroalkenes with a good tolerance for various functional groups.

中文翻译：

跨亲电偶联过程中CF和CN键断裂的合并，用于合成宝石-二氟烯烃。

在本文中，我们成功地将Katritzky盐作为烷基亲电子试剂用于与α-三氟甲基烯烃的还原性烯丙基脱氟交叉偶联反应中。通过镍和锌的协同作用将C-F和C-N键断裂合并在一起，可以有效合成对各种官能团具有良好耐受性的各种宝石-二氟烯烃。

更新日期：2020-07-17

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