Toward an AOP Network-Based Tiered Testing Strategy for the Assessment of Thyroid Hormone Disruption.,Environmental Science & Technology

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Toward an AOP Network-Based Tiered Testing Strategy for the Assessment of Thyroid Hormone Disruption.
Environmental Science & Technology ( IF 10.8 ) Pub Date : 2020-06-25 , DOI: 10.1021/acs.est.9b07205
Dries Knapen ₁ , Evelyn Stinckens ₁ , Jenna E Cavallin ₂ , Gerald T Ankley ₃ , Henrik Holbech ₄ , Daniel L Villeneuve ₃ , Lucia Vergauwen _{1,

5}

Affiliation

A growing number of environmental pollutants are known to adversely affect the thyroid hormone system, and major gaps have been identified in the tools available for the identification, and the hazard and risk assessment of these thyroid hormone disrupting chemicals. We provide an example of how the adverse outcome pathway (AOP) framework and associated data generation can address current testing challenges in the context of fish early life stage tests, and fish tests in general. We demonstrate how a suite of assays covering biological processes involved in the underlying toxicological pathways can be implemented in a tiered screening and testing approach for thyroid hormone disruption, using the levels of assessment of the OECD’s Conceptual Framework for the Testing and Assessment of Endocrine Disrupting Chemicals as a guide.

中文翻译：

迈向基于AOP网络的分层测试策略，以评估甲状腺激素干扰。

已知越来越多的环境污染物会对甲状腺激素系统产生不利影响，并且在可用于识别这些甲状腺激素破坏性化学物质以及危害和风险评估的工具中已经发现了重大差距。我们提供了一个示例，说明了不良结果途径（AOP）框架和相关数据生成如何在鱼类早期生命阶段测试以及一般鱼类测试中解决当前的测试挑战。我们证明了如何使用经合组织《内分泌干扰化学物质测试和评估概念框架》的评估水平，对甲状腺激素破坏的分层筛选和测试方法进行一套涵盖潜在毒理学途径中涉及的生物过程的测定方法作为指导。

更新日期：2020-07-21

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