Processing DNA-Based Molecular Signals into Graphical Displays.,ACS Synthetic Biology

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Processing DNA-Based Molecular Signals into Graphical Displays.
ACS Synthetic Biology ( IF 3.7 ) Pub Date : 2020-06-25 , DOI: 10.1021/acssynbio.0c00246
Arun Richard Chandrasekaran ₁

Affiliation

DNA is now well-established as a nanoscale building material with applications in fields such as biosensing and molecular computation. Molecular processes such as logic gates, nucleic acid circuits, and multiplexed detection have used different readout strategies to measure the output signal. In biosensing, this output can be the diagnosis of a disease biomarker, whereas in molecular computation, the output can be the result of a mathematical operation carried out using DNA. Recent developments have shown that the output of such processes can be displayed graphically as a macroscopic symbol or an alphanumeric character on multiwell plates, microarray chips, gels, lateral flow devices, and DNA origami surfaces. This review discusses the concepts behind such graphical readouts of molecular events, available display platforms, and the advantages and challenges in adapting such methods for practical use. Graphical display systems have the potential to be used in the creation of intelligent computing and sensing devices by which nanoscale binding events are translated into macroscopic visual readouts.

中文翻译：

将基于DNA的分子信号处理为图形显示。

现在，DNA已被广泛确立为一种纳米级建筑材料，并在生物传感和分子计算等领域得到应用。诸如逻辑门，核酸电路和多重检测之类的分子过程已经使用了不同的读出策略来测量输出信号。在生物传感中，该输出可以是疾病生物标志物的诊断，而在分子计算中，该输出可以是使用DNA进行数学运算的结果。最近的发展表明，此类过程的输出可以在多孔板，微阵列芯片，凝胶，侧向流动装置和DNA折纸表面上以图形化形式显示为宏观符号或字母数字字符。这篇评论讨论了分子事件的图形读数，可用的显示平台，以及将这些方法用于实际应用的优势和挑战。图形显示系统具有用于创建智能计算和传感设备的潜力，通过该设备，纳米级的结合事件可以转换为宏观的视觉读数。

更新日期：2020-07-17

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